Reaction Details Report a problem with these data
Target
Mu-type opioid receptor
Ligand
BDBM50001852
Substrate
n/a
Meas. Tech.
ChEBML_146420
IC50
0.045000±n/a nM
Citation
 Chandrakumar, NS; Yonan, PK; Stapelfeld, A; Savage, M; Rorbacher, E; Contreras, PC; Hammond, D Preparation and opioid activity of analogues of the analgesic dipeptide 2,6-dimethyl-L-tyrosyl-N-(3-phenylpropyl)-D-alaninamide. J Med Chem 35:223-33 (1992) [PubMed]  Article 
Target
Name:
Mu-type opioid receptor
Synonyms:
MOR-1 | MUOR1 | Mu-type opioid receptor (MOR) | OPIATE Mu | OPRM_RAT | Opiate non-selective | Opioid receptor B | Oprm1 | Ror-b
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
44503.11
Organism:
Rattus norvegicus (rat)
Description:
Competition binding assays were carried out using membrane preparations from transfected HN9.10 cells that constitutively expressed the mu opioid receptor.
Residue:
398
Sequence:
MDSSTGPGNTSDCSDPLAQASCSPAPGSWLNLSHVDGNQSDPCGLNRTGLGGNDSLCPQTGSPSMVTAITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGTWPFGTILCKIVISIDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWYWENLLKICVFIFAFIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKALITIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCFREFCIPTSSTIEQQNSTRVRQNTREHPSTANTVDRTNHQLENLEAETAPLP
  
Inhibitor
Name:
BDBM50001852
Synonyms:
2-Amino-3-(4-hydroxy-2,6-dimethyl-phenyl)-1-{2-[(3-phenyl-propylamino)-methyl]-piperidin-1-yl}-propan-1-one | CHEMBL74791
Type:
Small organic molecule
Emp. Form.:
C26H37N3O2
Mol. Mass.:
423.5909
SMILES:
Cc1cc(O)cc(C)c1CC(N)C(=O)N1CCCCC1CNCCCc1ccccc1
Structure:
Search PDB for entries with ligand similarity: