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Target
Substance-P receptor
Ligand
BDBM50002461
Substrate
n/a
Meas. Tech.
ChEBML_208650
IC50
180±n/a nM
Citation
 Lawrence, KB; Venepalli, BR; Appell, KC; Goswami, R; Logan, ME; Tomczuk, BE; Yanni, JM Synthesis and substance P antagonist activity of naphthimidazolium derivatives. J Med Chem 35:1273-9 (1992) [PubMed]  Article 
Target
Name:
Substance-P receptor
Synonyms:
NK-1 receptor | NK-1R | NK1 Receptor | NK1R_RAT | Neurokinin 1 receptor | Neurokinin NK1 | SPR | Substance-P receptor | Tac1r | Tachykinin receptor 1 | Tacr1
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
46371.54
Organism:
Rattus norvegicus (rat)
Description:
Competition binding assays were carried out using membrane preparations from transfected CHO cells that constitutively expressed the rat NK1 receptor.
Residue:
407
Sequence:
MDNVLPMDSDLFPNISTNTSESNQFVQPTWQIVLWAAAYTVIVVTSVVGNVVVIWIILAHKRMRTVTNYFLVNLAFAEACMAAFNTVVNFTYAVHNVWYYGLFYCKFHNFFPIAALFASIYSMTAVAFDRYMAIIHPLQPRLSATATKVVIFVIWVLALLLAFPQGYYSTTETMPSRVVCMIEWPEHPNRTYEKAYHICVTVLIYFLPLLVIGYAYTVVGITLWASEIPGDSSDRYHEQVSAKRKVVKMMIVVVCTFAICWLPFHVFFLLPYINPDLYLKKFIQQVYLASMWLAMSSTMYNPIIYCCLNDRFRLGFKHAFRCCPFISAGDYEGLEMKSTRYLQTQSSVYKVSRLETTISTVVGAHEEEPEEGPKATPSSLDLTSNGSSRSNSKTMTESSSFYSNMLA
  
Inhibitor
Name:
BDBM50002461
Synonyms:
10-Ethyl-1-[2-(3-ethyl-3H-benzothiazol-2-ylidene)-ethylidene]-3-methyl-1,2,3,10-tetrahydro-10-aza-3a-azonia-pentaleno[1,2-b]naphthalene; iodide | CHEMBL23096
Type:
Small organic molecule
Emp. Form.:
C28H28N3S
Mol. Mass.:
438.606
SMILES:
CCN1\C(Sc2ccccc12)=C/C=C1CC(C)[n+]2c1n(CC)c1cc3ccccc3cc21
Structure:
Search PDB for entries with ligand similarity: