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Target
5-hydroxytryptamine receptor 1D
Ligand
BDBM50003040
Substrate
n/a
Meas. Tech.
ChEBML_1631
IC50
1200±n/a nM
Citation
 Macor, JE; Fox, CB; Johnson, C; Koe, BK; Lebel, LA; Zorn, SH 1-(2-Aminoethyl)-3-methyl-8,9-dihydropyrano[3,2-e]indole: a rotationally restricted phenolic analog of the neurotransmitter serotonin and agonist selective for serotonin (5-HT2-type) receptors. J Med Chem 35:3625-32 (1992) [PubMed]  Article 
Target
Name:
5-hydroxytryptamine receptor 1D
Synonyms:
5-HT-1D | 5-HT-1D-alpha | 5-HT1D | 5-hydroxytryptamine receptor 1D (5-HT1D) | 5HT1D_HUMAN | HTR1D | HTR1DA | HTRL | Serotonin (5-HT) receptor | Serotonin Receptor 1D
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
41920.63
Organism:
Homo sapiens (Human)
Description:
Receptor binding assays were performed using human clone stably expressed in CHO cells.
Residue:
377
Sequence:
MSPLNQSAEGLPQEASNRSLNATETSEAWDPRTLQALKISLAVVLSVITLATVLSNAFVLTTILLTRKLHTPANYLIGSLATTDLLVSILVMPISIAYTITHTWNFGQILCDIWLSSDITCCTASILHLCVIALDRYWAITDALEYSKRRTAGHAATMIAIVWAISICISIPPLFWRQAKAQEEMSDCLVNTSQISYTIYSTCGAFYIPSVLLIILYGRIYRAARNRILNPPSLYGKRFTTAHLITGSAGSSLCSLNSSLHEGHSHSAGSPLFFNHVKIKLADSALERKRISAARERKATKILGIILGAFIICWLPFFVVSLVLPICRDSCWIHPALFDFFTWLGYLNSLINPIIYTVFNEEFRQAFQKIVPFRKAS
  
Inhibitor
Name:
BDBM50003040
Synonyms:
CHEMBL122860 | Dimethyl-[2-(1,6,7,8-tetrahydro-pyrano[2,3-f]indol-3-yl)-ethyl]-amine
Type:
Small organic molecule
Emp. Form.:
C15H20N2O
Mol. Mass.:
244.3321
SMILES:
CN(C)CCc1c[nH]c2cc3CCCOc3cc12
Structure:
Search PDB for entries with ligand similarity: