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Target
Type-1 angiotensin II receptor B
Ligand
BDBM50003264
Substrate
n/a
Meas. Tech.
ChEBML_34812
IC50
400±n/a nM
Citation
 Keenan, RM; Weinstock, J; Finkelstein, JA; Franz, RG; Gaitanopoulos, DE; Girard, GR; Hill, DT; Morgan, TM; Samanen, JM; Hempel, J Imidazole-5-acrylic acids: potent nonpeptide angiotensin II receptor antagonists designed using a novel peptide pharmacophore model. J Med Chem 35:3858-72 (1992) [PubMed]  Article 
Target
Name:
Type-1 angiotensin II receptor B
Synonyms:
AGTRB_RAT | AT3 | Agtr1 | Agtr1b | Angiotensin II AT1B | Angiotensin II receptor (AT-1) type-1 | Angiotensin II type 1b (AT-1b) receptor | At1b | Type-1B angiotensin II receptor
Type:
Enzyme Catalytic Domain
Mol. Mass.:
40929.44
Organism:
RAT
Description:
Angiotensin II AT1B 0 RAT::P29089
Residue:
359
Sequence:
MTLNSSTEDGIKRIQDDCPKAGRHNYIFVMIPTLYSIIFVVGIFGNSLVVIVIYFYMKLKTVASVFLLNLALADLCFLLTLPLWAVYTAMEYRWPFGNHLCKIASASVSFNLYASVFLLTCLSIDRYLAIVHPMKSRLRRTMLVAKVTCIIIWLMAGLASLPAVIYRNVYFIENTNITVCAFHYESQNSTLPIGLGLTKNILGFVFPFLIILTSYTLIWKALKKAYKIQKNTPRNDDIFRIIMAIVLFFFFSWVPHQIFTFLDVLIQLGIIRDCEIADIVDTAMPITICIAYFNNCLNPLFYGFLGKKFKKYFLQLLKYIPPTAKSHAGLSTKMSTLSYRPSDNMSSSAKKSASFFEVE
  
Inhibitor
Name:
BDBM50003264
Synonyms:
3-[2-Butyl-3-(2-chloro-benzyl)-3H-imidazol-4-yl]-2-(4-nitro-benzyl)-acrylic acid | CHEMBL340825
Type:
Small organic molecule
Emp. Form.:
C24H24ClN3O4
Mol. Mass.:
453.918
SMILES:
CCCCc1ncc(\C=C(/Cc2ccc(cc2)[N+]([O-])=O)C(O)=O)n1Cc1ccccc1Cl
Structure:
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