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Target
Cholecystokinin receptor type A
Ligand
BDBM50003662
Substrate
n/a
Meas. Tech.
ChEMBL_50055 (CHEMBL662424)
IC50
8.3±n/a nM
Citation
 Tilley, JW; Danho, W; Madison, V; Fry, D; Swistok, J; Makofske, R; Michalewsky, J; Schwartz, A; Weatherford, S; Triscari, J Analogs of CCK incorporating conformationally constrained replacements for Asp32. J Med Chem 35:4249-52 (1992) [PubMed]  Article 
Target
Name:
Cholecystokinin receptor type A
Synonyms:
CCKAR_RAT | Cckar | Cholecystokinin peripheral | Cholecystokinin receptor | Cholecystokinin receptor type A
Type:
Enzyme Catalytic Domain
Mol. Mass.:
49676.37
Organism:
RAT
Description:
Cholecystokinin central 0 RAT::P30551
Residue:
444
Sequence:
MSHSPARQHLVESSRMDVVDSLLMNGSNITPPCELGLENETLFCLDQPQPSKEWQSALQILLYSIIFLLSVLGNTLVITVLIRNKRMRTVTNIFLLSLAVSDLMLCLFCMPFNLIPNLLKDFIFGSAVCKTTTYFMGTSVSVSTFNLVAISLERYGAICRPLQSRVWQTKSHALKVIAATWCLSFTIMTPYPIYSNLVPFTKNNNQTANMCRFLLPSDAMQQSWQTFLLLILFLLPGIVMVVAYGLISLELYQGIKFDASQKKSAKEKKPSTGSSTRYEDSDGCYLQKSRPPRKLELQQLSSGSGGSRLNRIRSSSSAANLIAKKRVIRMLIVIVVLFFLCWMPIFSANAWRAYDTVSAEKHLSGTPISFILLLSYTSSCVNPIIYCFMNKRFRLGFMATFPCCPNPGPPGVRGEVGEEEDGRTIRALLSRYSYSHMSTSAPPP
  
Inhibitor
Name:
BDBM50003662
Synonyms:
4-{2-Acetylamino-2-[1-({[1-{1-[2-(1-carbamoyl-2-phenyl-ethylcarbamoyl)-pyrrolidine-1-carbonyl]-3-methylsulfanyl-propylcarbamoyl}-2-(1H-indol-3-yl)-ethylcarbamoyl]-methyl}-carbamoyl)-3-methylsulfanyl-propylcarbamoyl]-ethyl}-benzenesulfonic acid | CHEMBL407530
Type:
Small organic molecule
Emp. Form.:
C48H61N9O11S3
Mol. Mass.:
1036.247
SMILES:
CSCC[C@H](NC(=O)[C@H](Cc1ccc(cc1)S(O)(=O)=O)NC(C)=O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCSC)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(N)=O
Structure:
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