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Target
Thromboxane-A synthase
Ligand
BDBM50003759
Substrate
n/a
Meas. Tech.
ChEBML_209946
IC50
220±n/a nM
Citation
 Main, AJ; Bhagwat, SS; Boswell, C; Goldstein, R; Gude, C; Cohen, DS; Furness, P; Lee, W; Louzan, M Thromboxane receptor antagonism combined with thromboxane synthase inhibition. 3. Pyridinylalkyl-substituted 8-[(arylsulfonyl)amino]octanoic acids. J Med Chem 35:4366-72 (1992) [PubMed]  Article 
Target
Name:
Thromboxane-A synthase
Synonyms:
CYP5 | CYP5A1 | Cytochrome P450 5A1 | P450 TxA2 | TBXAS1 | THAS_HUMAN | TXA synthase | TXAS | TXS | Thromboxane A2 Synthase | Thromboxane A2 Synthase (P450 TxA2) | Thromboxane Alpha | Thromboxane prostanoid | Thromboxane synthase | Thromboxane-A synthase
Type:
Enzyme
Mol. Mass.:
60524.67
Organism:
Homo sapiens (Human)
Description:
P24557
Residue:
533
Sequence:
MEALGFLKLEVNGPMVTVALSVALLALLKWYSTSAFSRLEKLGLRHPKPSPFIGNLTFFRQGFWESQMELRKLYGPLCGYYLGRRMFIVISEPDMIKQVLVENFSNFTNRMASGLEFKSVADSVLFLRDKRWEEVRGALMSAFSPEKLNEMVPLISQACDLLLAHLKRYAESGDAFDIQRCYCNYTTDVVASVAFGTPVDSWQAPEDPFVKHCKRFFEFCIPRPILVLLLSFPSIMVPLARILPNKNRDELNGFFNKLIRNVIALRDQQAAEERRRDFLQMVLDARHSASPMGVQDFDIVRDVFSSTGCKPNPSRQHQPSPMARPLTVDEIVGQAFIFLIAGYEIITNTLSFATYLLATNPDCQEKLLREVDVFKEKHMAPEFCSLEEGLPYLDMVIAETLRMYPPAFRFTREAAQDCEVLGQRIPAGAVLEMAVGALHHDPEHWPSPETFNPERFTAEARQQHRPFTYLPFGAGPRSCLGVRLGLLEVKLTLLHVLHKFRFQACPETQVPLQLESKSALGPKNGVYIKIVSR
  
Inhibitor
Name:
BDBM50003759
Synonyms:
8-(4-Chloro-benzenesulfonylamino)-7-pyridin-3-yl-octanoic acid | 8-(4-Chloro-benzenesulfonylamino)-7-pyridin-3-yl-octanoic acid; hydrochloride | 8-(4-Chloro-benzenesulfonylamino)-7-pyridin-3-yl-octanoic acid; hydrochloride;hydrate | CHEMBL138325 | CHEMBL544377
Type:
Small organic molecule
Emp. Form.:
C19H23ClN2O4S
Mol. Mass.:
410.915
SMILES:
OC(=O)CCCCCC(CNS(=O)(=O)c1ccc(Cl)cc1)c1cccnc1
Structure:
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