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TargetThromboxane A2 Synthase (P450 TxA2)
LigandBDBM50003795
Substrate/Competitorn/a
Meas. Tech.ChEBML_209924
IC50 3±n/a nM
Citation Bhagwat, SSGude, CBoswell, CContardo, NCohen, DSDotson, RMathis, JLee, WFurness, PZoganas, H Thromboxane receptor antagonism combined with thromboxane synthase inhibition. 4. 8-[[(4-Chlorophenyl)sulfonyl]amino]-4-(3-(3-pyridinyl) propyl)octanoic acid and analogs. J Med Chem35:4373-83 (1992) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Thromboxane A2 Synthase (P450 TxA2)
Name:Thromboxane-A synthase
Synonyms:Cytochrome P450 5A1 | P450 TxA2 | TXA synthase | TXS | Thromboxane A2 Synthase | Thromboxane Alpha | Thromboxane prostanoid | Thromboxane synthase | Thromboxane-A synthase
Type:Enzyme
Mol. Mass.:60524.67
Organism:Homo sapiens (Human)
Description:P24557
Residue:533
Sequence:
MEALGFLKLEVNGPMVTVALSVALLALLKWYSTSAFSRLEKLGLRHPKPSPFIGNLTFFR
QGFWESQMELRKLYGPLCGYYLGRRMFIVISEPDMIKQVLVENFSNFTNRMASGLEFKSV
ADSVLFLRDKRWEEVRGALMSAFSPEKLNEMVPLISQACDLLLAHLKRYAESGDAFDIQR
CYCNYTTDVVASVAFGTPVDSWQAPEDPFVKHCKRFFEFCIPRPILVLLLSFPSIMVPLA
RILPNKNRDELNGFFNKLIRNVIALRDQQAAEERRRDFLQMVLDARHSASPMGVQDFDIV
RDVFSSTGCKPNPSRQHQPSPMARPLTVDEIVGQAFIFLIAGYEIITNTLSFATYLLATN
PDCQEKLLREVDVFKEKHMAPEFCSLEEGLPYLDMVIAETLRMYPPAFRFTREAAQDCEV
LGQRIPAGAVLEMAVGALHHDPEHWPSPETFNPERFTAEARQQHRPFTYLPFGAGPRSCL
GVRLGLLEVKLTLLHVLHKFRFQACPETQVPLQLESKSALGPKNGVYIKIVSR
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50003795
NameBDBM50003795
Synonyms:5-[1-Pyridin-3-yl-1-(3-trifluoromethyl-phenyl)-meth-(E)-ylideneaminooxy]-pentanoic acid | 5-[Pyridin-3-yl-(3-trifluoromethyl-phenyl)-methyleneaminooxy]-pentanoic acid | CHEMBL280728 | R-68070 | ridogrel
TypeSmall organic molecule
Emp. Form.C18H17F3N2O3
Mol. Mass.366.3344
SMILESOC(=O)CCCCO\N=C(\c1cccnc1)c1cccc(c1)C(F)(F)F
Structure
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n/a