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Target
5-hydroxytryptamine receptor 1B
Ligand
BDBM50081702
Substrate
n/a
Meas. Tech.
ChEBML_1836
IC50
5800±n/a nM
Citation
 Macor, JE; Blake, J; Fox, CB; Johnson, C; Koe, BK; Lebel, LA; Morrone, JM; Ryan, K; Schmidt, AW; Schulz, DW Synthesis and serotonergic pharmacology of the enantiomers of 3-[(N-methylpyrrolidin-2-yl)methyl]-5-methoxy-1H-indole: discovery of stereogenic differentiation in the aminoethyl side chain of the neurotransmitter serotonin. J Med Chem 35:4503-5 (1992) [PubMed]  Article 
Target
Name:
5-hydroxytryptamine receptor 1B
Synonyms:
5-HT-1B | 5-HT-1D-beta | 5-HT1B | 5-hydroxytryptamine receptor 1B (5-HT1B) | 5HT1B_HUMAN | HTR1B | HTR1DB | S12 | Serotonin (5-HT) receptor | Serotonin 1D beta receptor | Serotonin Receptor 1B
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
43579.17
Organism:
Homo sapiens (Human)
Description:
Receptor binding assays were performed using human clone stably expressed in CHO cells
Residue:
390
Sequence:
MEEPGAQCAPPPPAGSETWVPQANLSSAPSQNCSAKDYIYQDSISLPWKVLLVMLLALITLATTLSNAFVIATVYRTRKLHTPANYLIASLAVTDLLVSILVMPISTMYTVTGRWTLGQVVCDFWLSSDITCCTASILHLCVIALDRYWAITDAVEYSAKRTPKRAAVMIALVWVFSISISLPPFFWRQAKAEEEVSECVVNTDHILYTVYSTVGAFYFPTLLLIALYGRIYVEARSRILKQTPNRTGKRLTRAQLITDSPGSTSSVTSINSRVPDVPSESGSPVYVNQVKVRVSDALLEKKKLMAARERKATKTLGIILGAFIVCWLPFFIISLVMPICKDACWFHLAIFDFFTWLGYLNSLINPIIYTMSNEDFKQAFHKLIRFKCTS
  
Inhibitor
Name:
BDBM50081702
Synonyms:
5-Methoxy-3-((S)-1-methyl-pyrrolidin-2-ylmethyl)-1H-indole | CHEMBL133939
Type:
Small organic molecule
Emp. Form.:
C15H20N2O
Mol. Mass.:
244.3321
SMILES:
COc1ccc2[nH]cc(C[C@@H]3CCCN3C)c2c1
Structure:
Search PDB for entries with ligand similarity: