Reaction Details Report a problem with these data
Target
Phospholipase A2, major isoenzyme
Ligand
BDBM50004677
Substrate
n/a
Meas. Tech.
ChEBML_155878
IC50
>1000000±n/a nM
Citation
 Wright, SW; Harris, RR; Collins, RJ; Corbett, RL; Green, AM; Wadman, EA; Batt, DG Novel 1-(pyridylphenyl)-1-phenyl-2-imidazolylethanols with topical antiinflammatory activity. J Med Chem 35:3148-55 (1992) [PubMed]  Article 
Target
Name:
Phospholipase A2, major isoenzyme
Synonyms:
Group IB phospholipase A2 | PA21B_PIG | PLA2G1B | Phosphatidylcholine 2-acylhydrolase | Phospholipase A2
Type:
Hydrolase; monomer or homodimer
Mol. Mass.:
16279.83
Organism:
Sus scrofa (pig)
Description:
Purchased from Sigma.
Residue:
146
Sequence:
MKFLVLAVLLTVGAAQEGISSRALWQFRSMIKCAIPGSHPLMDFNNYGCYCGLGGSGTPVDELDRCCETHDNCYRDAKNLDSCKFLVDNPYTESYSYSCSNTEITCNSKNNACEAFICNCDRNAAICFSKAPYNKEHKNLDTKKYC
  
Inhibitor
Name:
BDBM50004677
Synonyms:
Acetic acid 4-acetoxy-6-chloro-2,3-dimethoxy-naphthalen-1-yl ester | Acetic acid 4-acetoxy-6-chloro-2,3-dimethoxy-naphthalen-1-yl ester (Ionapalene) | Acetic acid 4-acetoxy-6-chloro-2,3-dimethoxy-naphthalen-1-yl ester (lonapalane) | Acetic acid 4-acetoxy-7-chloro-2,3-dimethoxy-naphthalen-1-yl ester | CHEMBL36648 | Lonapalene | RS-43179
Type:
Small organic molecule
Emp. Form.:
C16H15ClO6
Mol. Mass.:
338.74
SMILES:
COc1c(OC)c(OC(C)=O)c2cc(Cl)ccc2c1OC(C)=O
Structure:
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