Reaction Details Report a problem with these data
Target
Adenosine receptor A1
Ligand
BDBM50004724
Substrate
n/a
Meas. Tech.
ChEMBL_28536 (CHEMBL636726)
IC50
4300±n/a nM
Citation
 Peet, NP; Lentz, NL; Sunder, S; Dudley, MW; Ogden, AM Conformationally restrained, chiral (phenylisopropyl)amino-substituted pyrazolo[3,4-d]pyrimidines and purines with selectivity for adenosine A1 and A2 receptors. J Med Chem 35:3263-9 (1992) [PubMed]  Article 
Target
Name:
Adenosine receptor A1
Synonyms:
AA1R_RAT | ADENOSINE A1 | ADENOSINE A1 high | ADENOSINE A1 low | Adenosine A1 receptor (A1) | Adenosine receptor | Adenosine receptors A1 | Adora1
Type:
Protein
Mol. Mass.:
36704.13
Organism:
Rattus norvegicus (rat)
Description:
n/a
Residue:
326
Sequence:
MPPYISAFQAAYIGIEVLIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIPLAILINIGPQTYFHTCLMVACPVLILTQSSILALLAIAVDRYLRVKIPLRYKTVVTQRRAAVAIAGCWILSLVVGLTPMFGWNNLSVVEQDWRANGSVGEPVIKCEFEKVISMEYMVYFNFFVWVLPPLLLMVLIYLEVFYLIRKQLNKKVSASSGDPQKYYGKELKIAKSLALILFLFALSWLPLHILNCITLFCPTCQKPSILIYIAIFLTHGNSAMNPIVYAFRIHKFRVTFLKIWNDHFRCQPKPPIDEDLPEEKAED
  
Inhibitor
Name:
BDBM50004724
Synonyms:
5-Methyl-1-phenyl-6-propoxy-1,5-dihydro-pyrazolo[3,4-d]pyrimidin-4-one | CHEMBL109310
Type:
Small organic molecule
Emp. Form.:
C15H16N4O2
Mol. Mass.:
284.3131
SMILES:
CCCOc1nc2n(ncc2c(=O)n1C)-c1ccccc1
Structure:
Search PDB for entries with ligand similarity: