Reaction Details Report a problem with these data
Target
Renin
Ligand
BDBM50005300
Substrate
n/a
Meas. Tech.
ChEBML_195740
IC50
186±n/a nM
Citation
Ocain, TD; Deininger, DD; Russo, R; Senko, NA; Katz, A; Kitzen, JM; Mitchell, R; Oshiro, G; Russo, A; Stupienski, R New modified heterocyclic phenylalanine derivatives. Incorporation into potent inhibitors of human renin. J Med Chem 35:823-32 (1992) [PubMed] Article
More Info.:
Target
Name:
Renin
Synonyms:
Angiotensinogenase | REN | RENI_HUMAN
Type:
Enzyme
Mol. Mass.:
45058.99
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
406
Sequence:
MDGWRRMPRWGLLLLLWGSCTFGLPTDTTTFKRIFLKRMPSIRESLKERGVDMARLGPEWSQPMKRLTLGNTTSSVILTNYMDTQYYGEIGIGTPPQTFKVVFDTGSSNVWVPSSKCSRLYTACVYHKLFDASDSSSYKHNGTELTLRYSTGTVSGFLSQDIITVGGITVTQMFGEVTEMPALPFMLAEFDGVVGMGFIEQAIGRVTPIFDNIISQGVLKEDVFSFYYNRDSENSQSLGGQIVLGGSDPQHYEGNFHYINLIKTGVWQIQMKGVSVGSSTLLCEDGCLALVDTGASYISGSTSSIEKLMEALGAKKRLFDYVVKCNEGPTLPDISFHLGGKEYTLTSADYVFQESYSSKKLCTLAIHAMDIPPPTGPTWALGATFIRKFYTEFDRRNNRIGFALAR
Inhibitor
Name:
BDBM50005300
Synonyms:
4-Cyclohexyl-2-hydroxy-3-{3-(1H-imidazol-4-yl)-2-[2-(1-oxo-1,3-dihydro-isoindol-2-yl)-3-phenyl-propionylamino]-propionylamino}-butyric acid methyl ester | CHEMBL353061
Type:
Small organic molecule
Emp. Form.:
C34H41N5O6
Mol. Mass.:
615.7192
SMILES:
COC(=O)C(O)[C@H](CC1CCCCC1)NC(=O)C(Cc1cnc[nH]1)NC(=O)[C@H](Cc1ccccc1)N1Cc2ccccc2C1=O