Target
Renin
Ligand
BDBM50005310
Substrate
n/a
Meas. Tech.
ChEBML_195740
IC50
391±n/a nM
Citation
 Ocain, TDDeininger, DDRusso, RSenko, NAKatz, AKitzen, JMMitchell, ROshiro, GRusso, AStupienski, R New modified heterocyclic phenylalanine derivatives. Incorporation into potent inhibitors of human renin. J Med Chem 35:823-32 (1992) [PubMed]  Article 
Target
Name:
Renin
Synonyms:
Angiotensinogenase | REN | RENI_HUMAN
Type:
Enzyme
Mol. Mass.:
45058.99
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
406
Sequence:
MDGWRRMPRWGLLLLLWGSCTFGLPTDTTTFKRIFLKRMPSIRESLKERGVDMARLGPEWSQPMKRLTLGNTTSSVILTNYMDTQYYGEIGIGTPPQTFKVVFDTGSSNVWVPSSKCSRLYTACVYHKLFDASDSSSYKHNGTELTLRYSTGTVSGFLSQDIITVGGITVTQMFGEVTEMPALPFMLAEFDGVVGMGFIEQAIGRVTPIFDNIISQGVLKEDVFSFYYNRDSENSQSLGGQIVLGGSDPQHYEGNFHYINLIKTGVWQIQMKGVSVGSSTLLCEDGCLALVDTGASYISGSTSSIEKLMEALGAKKRLFDYVVKCNEGPTLPDISFHLGGKEYTLTSADYVFQESYSSKKLCTLAIHAMDIPPPTGPTWALGATFIRKFYTEFDRRNNRIGFALAR
  
Inhibitor
Name:
BDBM50005310
Synonyms:
4-Cyclohexyl-3-{2-[2-(1,3-dioxo-1H,3H-benzo[de]isoquinolin-2-yl)-3-phenyl-propionylamino]-4-methyl-pentanoylamino}-2-hydroxy-butyric acid methyl ester | CHEMBL167744
Type:
Small organic molecule
Emp. Form.:
C38H45N3O7
Mol. Mass.:
655.7798
SMILES:
COC(=O)C(O)[C@H](CC1CCCCC1)NC(=O)C(CC(C)C)NC(=O)[C@H](Cc1ccccc1)N1C(=O)c2cccc3cccc(C1=O)c23
Structure:
Search PDB for entries with ligand similarity: