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Target
Muscarinic acetylcholine receptor
Ligand
BDBM50005363
Substrate
n/a
Meas. Tech.
ChEMBL_138226 (CHEMBL744917)
EC50
16±n/a nM
Citation
 Showell, GA; Baker, R; Davis, J; Hargreaves, R; Freedman, SB; Hoogsteen, K; Patel, S; Snow, RJ Synthesis and in vitro biological profile of all four isomers of the potent muscarinic agonist 3-(3-methyl-1,2,4-oxadiazol-5-yl)-1-azabicyclo[2.2.1]heptane. J Med Chem 35:911-6 (1992) [PubMed]  Article 
Target
Name:
Muscarinic acetylcholine receptor
Synonyms:
GPM3 | Muscarinic acetylcholine receptor M3
Type:
n/a
Mol. Mass.:
66272.13
Organism:
Cavia porcellus
Description:
n/a
Residue:
587
Sequence:
MTLHSNSTTLPLFPNISTSWIHSPSEAGLPPGTVTHFGSYNISQAAGNFSSLNGTTSDPLGGHTIWQVVFIAFLTGFLALVTIIGNILVIVSFKVNKQLKHVNNYFLLSLADLIIGVISMNLFTTYIIMNRWALGNLACDLWLSIDYVASNASVMNLLVISFDRYFSITRPLTYRAKRTTKRAGVMIGLAWVISFVLWAPAILFWQYFVGKRTVPPGECFIQFLSEPTITFGTAIAAFYMPVTIMTILYWRIYKETEKRTKELAGLQASGTEAETENFVHPTGSSRSCSSYELQQQSLKHSSRRKYSRCHFWFATKSWKPNAGQMDQDHSSSDSWNNYDAAASLENSASDEEDIGSETRAIYSIVLKLPGHSTILNSTKLPSSDNLQVPEEDLEPMDMERNASKPQTQKSMDDGGSFQKSFSNLPIQLESTMDTAKTSDANSSVSKTMATLPLSFKEATLAKRFALRTRSQITKRKRMSLIKEKRAAQTLSAILLAFIITWTPYNIMVLVNTFCDSCIPKTYWNLGYWLCYINSTVNPVCYALCNKTFRNTFKMLLLCQCDKRKRRKQQYQQRQSVIFHKRVPEQAL
  
Inhibitor
Name:
BDBM50005363
Synonyms:
(3R,4R)3-(3-Methyl-[1,2,4]oxadiazol-5-yl)-1-aza-bicyclo[2.2.1]heptane | (3R,4S)3-(3-Methyl-[1,2,4]oxadiazol-5-yl)-1-aza-bicyclo[2.2.1]heptane | (3S,4S)3-(3-Methyl-[1,2,4]oxadiazol-5-yl)-1-aza-bicyclo[2.2.1]heptane | 3-(3-Methyl-[1,2,4]oxadiazol-5-yl)-1-aza-bicyclo[2.2.1]heptane | CHEMBL92421
Type:
Small organic molecule
Emp. Form.:
C9H13N3O
Mol. Mass.:
179.219
SMILES:
Cc1noc(n1)C1CN2CCC1C2 |TLB:4:6:12:10.9|
Structure:
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