Reaction Details Report a problem with these data
Target
Advanced glycosylation end product-specific receptor
Ligand
BDBM50249575
Substrate
n/a
Meas. Tech.
ChEBML_1680057
Kd
3.0±n/a nM
Citation
 Bongarzone, S; Savickas, V; Luzi, F; Gee, AD Targeting the Receptor for Advanced Glycation Endproducts (RAGE): A Medicinal Chemistry Perspective. J Med Chem 60:7213-7232 (2017) [PubMed]  Article 
Target
Name:
Advanced glycosylation end product-specific receptor
Synonyms:
AGER | RAGE | RAGE_HUMAN | Receptor for advanced glycosylation end products
Type:
PROTEIN
Mol. Mass.:
42800.11
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1339877
Residue:
404
Sequence:
MAAGTAVGAWVLVLSLWGAVVGAQNITARIGEPLVLKCKGAPKKPPQRLEWKLNTGRTEAWKVLSPQGGGPWDSVARVLPNGSLFLPAVGIQDEGIFRCQAMNRNGKETKSNYRVRVYQIPGKPEIVDSASELTAGVPNKVGTCVSEGSYPAGTLSWHLDGKPLVPNEKGVSVKEQTRRHPETGLFTLQSELMVTPARGGDPRPTFSCSFSPGLPRHRALRTAPIQPRVWEPVPLEEVQLVVEPEGGAVAPGGTVTLTCEVPAQPSPQIHWMKDGVPLPLPPSPVLILPEIGPQDQGTYSCVATHSSHGPQESRAVSISIIEPGEEGPTAGSVGGSGLGTLALALGILGGLGTAALLIGVILWQRRQRRGEERKAPENQEEEEERAELNQSEEPEAGESSTGGP
  
Inhibitor
Name:
BDBM50249575
Synonyms:
CHEMBL4100986 | US10729695, Compound CB-10
Type:
Small organic molecule
Emp. Form.:
C16H20N4O
Mol. Mass.:
284.3562
SMILES:
CC(C)CCC1C(C)=NN(C1=O)c1nc2ccccc2[nH]1 |c:7|
Structure:
Search PDB for entries with ligand similarity: