Reaction Details Report a problem with these data
Target
Renin
Ligand
BDBM50005430
Substrate
n/a
Meas. Tech.
ChEBML_192717
IC50
74±n/a nM
Citation
Repine, JT; Kaltenbronn, JS; Doherty, AM; Hamby, JM; Himmelsbach, RJ; Kornberg, BE; Taylor, MD; Lunney, EA; Humblet, C; Rapundalo, ST Renin inhibitors containing alpha-heteroatom amino acids as P2 residues. J Med Chem 35:1032-42 (1992) [PubMed] Article
More Info.:
Target
Name:
Renin
Synonyms:
Angiotensinogenase | REN | RENI_HUMAN
Type:
Enzyme
Mol. Mass.:
45058.99
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
406
Sequence:
MDGWRRMPRWGLLLLLWGSCTFGLPTDTTTFKRIFLKRMPSIRESLKERGVDMARLGPEWSQPMKRLTLGNTTSSVILTNYMDTQYYGEIGIGTPPQTFKVVFDTGSSNVWVPSSKCSRLYTACVYHKLFDASDSSSYKHNGTELTLRYSTGTVSGFLSQDIITVGGITVTQMFGEVTEMPALPFMLAEFDGVVGMGFIEQAIGRVTPIFDNIISQGVLKEDVFSFYYNRDSENSQSLGGQIVLGGSDPQHYEGNFHYINLIKTGVWQIQMKGVSVGSSTLLCEDGCLALVDTGASYISGSTSSIEKLMEALGAKKRLFDYVVKCNEGPTLPDISFHLGGKEYTLTSADYVFQESYSSKKLCTLAIHAMDIPPPTGPTWALGATFIRKFYTEFDRRNNRIGFALAR
Inhibitor
Name:
BDBM50005430
Synonyms:
4-[2-Dimethylamino-2-(3-naphthalen-1-yl-2-naphthalen-1-ylmethyl-propionylamino)-acetylamino]-3-hydroxy-6-methyl-heptanoic acid (2-methyl-butyl)-amide | CHEMBL3350018
Type:
Small organic molecule
Emp. Form.:
C41H54N4O4
Mol. Mass.:
666.8919
SMILES:
CC[C@H](C)CNC(=O)C[C@H](O)[C@H](CC(C)C)NC(=O)C(NC(=O)C(Cc1cccc2ccccc12)Cc1cccc2ccccc12)N(C)C