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Target
Renin
Ligand
BDBM50005424
Substrate
n/a
Meas. Tech.
ChEMBL_196280 (CHEMBL806634)
IC50
500±n/a nM
Citation
 Repine, JT; Kaltenbronn, JS; Doherty, AM; Hamby, JM; Himmelsbach, RJ; Kornberg, BE; Taylor, MD; Lunney, EA; Humblet, C; Rapundalo, ST Renin inhibitors containing alpha-heteroatom amino acids as P2 residues. J Med Chem 35:1032-42 (1992) [PubMed]  Article 
Target
Name:
Renin
Synonyms:
Angiotensinogenase | REN | RENI_HUMAN
Type:
Enzyme
Mol. Mass.:
45058.99
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
406
Sequence:
MDGWRRMPRWGLLLLLWGSCTFGLPTDTTTFKRIFLKRMPSIRESLKERGVDMARLGPEWSQPMKRLTLGNTTSSVILTNYMDTQYYGEIGIGTPPQTFKVVFDTGSSNVWVPSSKCSRLYTACVYHKLFDASDSSSYKHNGTELTLRYSTGTVSGFLSQDIITVGGITVTQMFGEVTEMPALPFMLAEFDGVVGMGFIEQAIGRVTPIFDNIISQGVLKEDVFSFYYNRDSENSQSLGGQIVLGGSDPQHYEGNFHYINLIKTGVWQIQMKGVSVGSSTLLCEDGCLALVDTGASYISGSTSSIEKLMEALGAKKRLFDYVVKCNEGPTLPDISFHLGGKEYTLTSADYVFQESYSSKKLCTLAIHAMDIPPPTGPTWALGATFIRKFYTEFDRRNNRIGFALAR
  
Inhibitor
Name:
BDBM50005424
Synonyms:
3-Hydroxy-4-[2-isopropylamino-2-(3-naphthalen-1-yl-2-naphthalen-1-ylmethyl-propionylamino)-acetylamino]-6-methyl-heptanoic acid (2-methyl-butyl)-amide | CHEMBL3350020
Type:
Small organic molecule
Emp. Form.:
C42H56N4O4
Mol. Mass.:
680.9184
SMILES:
CC[C@H](C)CNC(=O)C[C@H](O)[C@H](CC(C)C)NC(=O)C(NC(C)C)NC(=O)C(Cc1cccc2ccccc12)Cc1cccc2ccccc12
Structure:
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