Target
Renin
Ligand
BDBM50006160
Substrate
n/a
Meas. Tech.
ChEBML_195793
pH
7.4±n/a
IC50
85±n/a nM
Comments
extracted
Citation
 Baker, WRFung, AKKleinert, HDStein, HHPlattner, JJArmiger, YLCondon, SLCohen, JEgan, DABarlow, JL Nonpeptide renin inhibitors employing a novel 3-aza(or oxa)-2,4-dialkyl glutaric acid moiety as a P2/P3 amide bond replacement. J Med Chem 35:1722-34 (1992) [PubMed]  Article 
Target
Name:
Renin
Synonyms:
Angiotensinogenase | REN | RENI_HUMAN
Type:
Enzyme
Mol. Mass.:
45058.99
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
406
Sequence:
MDGWRRMPRWGLLLLLWGSCTFGLPTDTTTFKRIFLKRMPSIRESLKERGVDMARLGPEWSQPMKRLTLGNTTSSVILTNYMDTQYYGEIGIGTPPQTFKVVFDTGSSNVWVPSSKCSRLYTACVYHKLFDASDSSSYKHNGTELTLRYSTGTVSGFLSQDIITVGGITVTQMFGEVTEMPALPFMLAEFDGVVGMGFIEQAIGRVTPIFDNIISQGVLKEDVFSFYYNRDSENSQSLGGQIVLGGSDPQHYEGNFHYINLIKTGVWQIQMKGVSVGSSTLLCEDGCLALVDTGASYISGSTSSIEKLMEALGAKKRLFDYVVKCNEGPTLPDISFHLGGKEYTLTSADYVFQESYSSKKLCTLAIHAMDIPPPTGPTWALGATFIRKFYTEFDRRNNRIGFALAR
  
Inhibitor
Name:
BDBM50006160
Synonyms:
2-(1-Benzyl-2-morpholin-4-yl-2-oxo-ethylamino)-N-(1-cyclohexylmethyl-2,3-dihydroxy-5-methyl-hexyl)-propionamide | CHEMBL49804
Type:
Small organic molecule
Emp. Form.:
C30H49N3O5
Mol. Mass.:
531.7272
SMILES:
CC(C)C[C@H](O)[C@H](O)[C@H](CC1CCCCC1)NC(=O)C(C)N[C@@H](Cc1ccccc1)C(=O)N1CCOCC1
Structure:
Search PDB for entries with ligand similarity: