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Target
Adenosylhomocysteinase
Ligand
BDBM50006218
Substrate
n/a
Meas. Tech.
ChEBML_196726
Ki
12±n/a nM
Citation
 Wolfe, MS; Lee, Y; Bartlett, WJ; Borcherding, DR; Borchardt, RT 4'-modified analogues of aristeromycin and neplanocin A: synthesis and inhibitory activity toward S-adenosyl-L-homocysteine hydrolase. J Med Chem 35:1782-91 (1992) [PubMed]  Article 
Target
Name:
Adenosylhomocysteinase
Synonyms:
AHCY | Adenosylhomocysteinase | SAHH | SAHH_HUMAN
Type:
PROTEIN
Mol. Mass.:
47714.06
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1507791
Residue:
432
Sequence:
MSDKLPYKVADIGLAAWGRKALDIAENEMPGLMRMRERYSASKPLKGARIAGCLHMTVETAVLIETLVTLGAEVQWSSCNIFSTQDHAAAAIAKAGIPVYAWKGETDEEYLWCIEQTLYFKDGPLNMILDDGGDLTNLIHTKYPQLLPGIRGISEETTTGVHNLYKMMANGILKVPAINVNDSVTKSKFDNLYGCRESLIDGIKRATDVMIAGKVAVVAGYGDVGKGCAQALRGFGARVIITEIDPINALQAAMEGYEVTTMDEACQEGNIFVTTTGCIDIILGRHFEQMKDDAIVCNIGHFDVEIDVKWLNENAVEKVNIKPQVDRYRLKNGRRIILLAEGRLVNLGCAMGHPSFVMSNSFTNQVMAQIELWTHPDKYPVGVHFLPKKLDEAVAEAHLGKLNVKLTKLTEKQAQYLGMSCDGPFKPDHYRY
  
Inhibitor
Name:
BDBM50006218
Synonyms:
(1R,2S,3R)-3-(6-amino-9H-purin-9-yl)cyclopentane-1,2-diol | 3-(6-Amino-purin-9-yl)-cyclopentane-1,2-diol | CHEMBL301499
Type:
Small organic molecule
Emp. Form.:
C10H13N5O2
Mol. Mass.:
235.2425
SMILES:
Nc1ncnc2n(cnc12)[C@@H]1CC[C@@H](O)[C@H]1O
Structure:
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