Target
Aldo-keto reductase family 1 member B1
Ligand
BDBM50006401
Substrate
n/a
Meas. Tech.
ChEBML_31912
IC50
860±n/a nM
Citation
 Yamagishi, MYamada, YOzaki, KAsao, MShimizu, RSuzuki, MMatsumoto, MMatsuoka, YMatsumoto, K Biological activities and quantitative structure-activity relationships of spiro[imidazolidine-4,4'(1'H)-quinazoline]-2,2',5(3'H)-triones as aldose reductase inhibitors. J Med Chem 35:2085-94 (1992) [PubMed]  Article 
Target
Name:
Aldo-keto reductase family 1 member B1
Synonyms:
AKR1B1 | ALDR1 | ALDR_HUMAN | ALR2 | AR | Aldo-keto reductase family 1 member B1 (AKR1B1) | Aldose Reductase (ALR2) | Aldose reductase | Aldose reductase (AR)
Type:
Protein
Mol. Mass.:
35855.50
Organism:
Homo sapiens (Human)
Description:
P15121. 4LAU; 2IKI; 4LB4; 2FZD; 2FZ8; 1US0
Residue:
316
Sequence:
MASRLLLNNGAKMPILGLGTWKSPPGQVTEAVKVAIDVGYRHIDCAHVYQNENEVGVAIQEKLREQVVKREELFIVSKLWCTYHEKGLVKGACQKTLSDLKLDYLDLYLIHWPTGFKPGKEFFPLDESGNVVPSDTNILDTWAAMEELVDEGLVKAIGISNFNHLQVEMILNKPGLKYKPAVNQIECHPYLTQEKLIQYCQSKGIVVTAYSPLGSPDRPWAKPEDPSLLEDPRIKAIAAKHNKTTAQVLIRFPMQRNLVVIPKSVTPERIAENFKVFDFELSSQDMTTLLSYNRNWRVCALLSCTSHKDYPFHEEF
  
Inhibitor
Name:
BDBM50006401
Synonyms:
5'-chloro-3'-methyl-1'H,2H,5H-spiro[imidazolidine-4,4'-quinazoline]-2,2',5(3'H)-trione | CHEMBL63866
Type:
Small organic molecule
Emp. Form.:
C11H9ClN4O3
Mol. Mass.:
280.667
SMILES:
CN1C(=O)Nc2cccc(Cl)c2C11NC(=O)NC1=O
Structure:
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