| Reaction Details |
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 | Report a problem with these data |
| Target | Renin |
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| Ligand | BDBM50006433 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_196103 |
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| IC50 | 124±n/a nM |
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| Citation |  Ashton, WT; Cantone, CL; Meurer, LC; Tolman, RL; Greenlee, WJ; Patchett, AA; Lynch, RJ; Schorn, TW; Strouse, JF; Siegl, PK Renin inhibitors containing C-termini derived from mercaptoheterocycles. J Med Chem35:2103-12 (1992) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Renin |
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| Name: | Renin |
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| Synonyms: | Angiotensinogenase |
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| Type: | Enzyme |
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| Mol. Mass.: | 45058.99 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 406 |
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| Sequence: | MDGWRRMPRWGLLLLLWGSCTFGLPTDTTTFKRIFLKRMPSIRESLKERGVDMARLGPEW
SQPMKRLTLGNTTSSVILTNYMDTQYYGEIGIGTPPQTFKVVFDTGSSNVWVPSSKCSRL
YTACVYHKLFDASDSSSYKHNGTELTLRYSTGTVSGFLSQDIITVGGITVTQMFGEVTEM
PALPFMLAEFDGVVGMGFIEQAIGRVTPIFDNIISQGVLKEDVFSFYYNRDSENSQSLGG
QIVLGGSDPQHYEGNFHYINLIKTGVWQIQMKGVSVGSSTLLCEDGCLALVDTGASYISG
STSSIEKLMEALGAKKRLFDYVVKCNEGPTLPDISFHLGGKEYTLTSADYVFQESYSSKK
LCTLAIHAMDIPPPTGPTWALGATFIRKFYTEFDRRNNRIGFALAR
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| BDBM50006433 |
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| Name | BDBM50006433 |
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| Synonyms: | CHEMBL406475 | {1-[1-[1-Cyclohexylmethyl-2-hydroxy-3-(1-methyl-1H-imidazol-2-ylsulfanyl)-propylcarbamoyl]-2-(1H-imidazol-4-yl)-ethylcarbamoyl]-2-phenyl-ethyl}-carbamic acid tert-butyl ester; hydrate |
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| Type | Small organic molecule |
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| Emp. Form. | C34H49N7O5S |
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| Mol. Mass. | 667.862 |
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| SMILES | Cn1ccnc1SC[C@H](O)[C@H](CC1CCCCC1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](Cc1ccccc1)NC(=O)OC(C)(C)C |
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| Structure | 
|
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| n/a |
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