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TargetAldose reductase (AR)
LigandBDBM50006461
Substrate/Competitorn/a
Meas. Tech.ChEBML_31769
IC50 32±n/a nM
Citation Mylari, BLZembrowski, WJBeyer, TAAldinger, CESiegel, TW Orally active aldose reductase inhibitors: indazoleacetic, oxopyridazineacetic, and oxopyridopyridazineacetic acid derivatives. J Med Chem35:2155-62 (1992) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Aldose reductase (AR)
Name:Aldose reductase
Synonyms:AR | Aldo-keto reductase family 1 member B1 (AKR1B1) | Aldose Reductase (ALR2) | Aldose reductase
Type:Protein
Mol. Mass.:35855.50
Organism:Homo sapiens (Human)
Description:P15121. 4LAU; 2IKI; 4LB4; 2FZD; 2FZ8; 1US0
Residue:316
Sequence:
MASRLLLNNGAKMPILGLGTWKSPPGQVTEAVKVAIDVGYRHIDCAHVYQNENEVGVAIQ
EKLREQVVKREELFIVSKLWCTYHEKGLVKGACQKTLSDLKLDYLDLYLIHWPTGFKPGK
EFFPLDESGNVVPSDTNILDTWAAMEELVDEGLVKAIGISNFNHLQVEMILNKPGLKYKP
AVNQIECHPYLTQEKLIQYCQSKGIVVTAYSPLGSPDRPWAKPEDPSLLEDPRIKAIAAK
HNKTTAQVLIRFPMQRNLVVIPKSVTPERIAENFKVFDFELSSQDMTTLLSYNRNWRVCA
LLSCTSHKDYPFHEEF
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50006461
NameBDBM50006461
Synonyms:CHEMBL66006 | [3-(4-Bromo-2-fluoro-benzyl)-4-oxo-3,4,5,6,7,8-hexahydro-phthalazin-1-yl]-acetic acid
TypeSmall organic molecule
Emp. Form.C17H16BrFN2O3
Mol. Mass.395.223
SMILESOC(=O)Cc1nn(Cc2ccc(Br)cc2F)c(=O)c2CCCCc12
Structure
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n/a