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TargetAldose reductase
LigandBDBM50229580
Substrate/Competitorn/a
Meas. Tech.ChEMBL_31769
IC50<10±n/a nM
Citation Mylari, BLZembrowski, WJBeyer, TAAldinger, CESiegel, TW Orally active aldose reductase inhibitors: indazoleacetic, oxopyridazineacetic, and oxopyridopyridazineacetic acid derivatives. J Med Chem35:2155-62 (1992) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Aldose reductase
Name:Aldose reductase
Synonyms:AR | Aldo-keto reductase family 1 member B1 (AKR1B1) | Aldose Reductase (ALR2) | Aldose reductase
Type:Protein
Mol. Mass.:35855.50
Organism:Homo sapiens (Human)
Description:P15121. 4LAU; 2IKI; 4LB4; 2FZD; 2FZ8; 1US0
Residue:316
Sequence:
MASRLLLNNGAKMPILGLGTWKSPPGQVTEAVKVAIDVGYRHIDCAHVYQNENEVGVAIQ
EKLREQVVKREELFIVSKLWCTYHEKGLVKGACQKTLSDLKLDYLDLYLIHWPTGFKPGK
EFFPLDESGNVVPSDTNILDTWAAMEELVDEGLVKAIGISNFNHLQVEMILNKPGLKYKP
AVNQIECHPYLTQEKLIQYCQSKGIVVTAYSPLGSPDRPWAKPEDPSLLEDPRIKAIAAK
HNKTTAQVLIRFPMQRNLVVIPKSVTPERIAENFKVFDFELSSQDMTTLLSYNRNWRVCA
LLSCTSHKDYPFHEEF
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50229580
NameBDBM50229580
Synonyms:CHEMBL66920
TypeSmall organic molecule
Emp. Form.C14H9F2N3O3S
Mol. Mass.337.301
SMILESOC(=O)Cc1ccc(=O)n(Cc2nc3cc(F)cc(F)c3s2)n1
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least:
n/a