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Target
Muscarinic acetylcholine receptor M1
Ligand
BDBM50006600
Substrate
n/a
Meas. Tech.
ChEMBL_138797 (CHEMBL751533)
IC50
860±n/a nM
Citation
 Sauerberg, P; Olesen, PH; Nielsen, S; Treppendahl, S; Sheardown, MJ; Honoré, T; Mitch, CH; Ward, JS; Pike, AJ; Bymaster, FP Novel functional M1 selective muscarinic agonists. Synthesis and structure-activity relationships of 3-(1,2,5-thiadiazolyl)-1,2,5,6-tetrahydro-1-methylpyridines . J Med Chem 35:2274-83 (1992) [PubMed]  Article 
Target
Name:
Muscarinic acetylcholine receptor M1
Synonyms:
ACM1_RAT | Cholinergic, muscarinic M1 | Chrm-1 | Chrm1 | cholinergic receptor, muscarinic 1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
51390.46
Organism:
RAT
Description:
P08482
Residue:
460
Sequence:
MNTSVPPAVSPNITVLAPGKGPWQVAFIGITTGLLSLATVTGNLLVLISFKVNTELKTVNNYFLLSLACADLIIGTFSMNLYTTYLLMGHWALGTLACDLWLALDYVASNASVMNLLLISFDRYFSVTRPLSYRAKRTPRRAALMIGLAWLVSFVLWAPAILFWQYLVGERTVLAGQCYIQFLSQPIITFGTAMAAFYLPVTVMCTLYWRIYRETENRARELAALQGSETPGKGGGSSSSSERSQPGAEGSPESPPGRCCRCCRAPRLLQAYSWKEEEEEDEGSMESLTSSEGEEPGSEVVIKMPMVDSEAQAPTKQPPKSSPNTVKRPTKKGRDRGGKGQKPRGKEQLAKRKTFSLVKEKKAARTLSAILLAFILTWTPYNIMVLVSTFCKDCVPETLWELGYWLCYVNSTVNPMCYALCNKAFRDTFRLLLLCRWDKRRWRKIPKRPGSVHRTPSRQC
  
Inhibitor
Name:
BDBM50006600
Synonyms:
5-[4-(Hexane-1-sulfinyl)-[1,2,5]thiadiazol-3-yl]-1-methyl-1,2,3,6-tetrahydro-pyridine | CHEMBL76296
Type:
Small organic molecule
Emp. Form.:
C14H23N3OS2
Mol. Mass.:
313.482
SMILES:
CCCCCCS(=O)c1nsnc1C1=CCCN(C)C1 |t:14|
Structure:
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