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TargetDual specificity phosphatase Cdc25A
LigandBDBM50251709
Substrate/Competitorn/a
Meas. Tech.ChEBML_1684262
IC50 3370±n/a nM
Citation Zwergel, CCzepukojc, BEvain-Bana, EXu, ZStazi, GMori, MPatsilinakos, AMai, ABotta, BRagno, RBagrel, DKirsch, GMeiser, PJacob, CMontenarh, MValente, S Novel coumarin- and quinolinone-based polycycles as cell division cycle 25-A and -C phosphatases inhibitors induce proliferation arrest and apoptosis in cancer cells. Eur J Med Chem134:316-333 (2017) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Dual specificity phosphatase Cdc25A
Name:Dual specificity phosphatase Cdc25A
Synonyms:Dual specificity phosphatase (Cdc25A) | Dual specificity phosphatase Cdc25A | M-phase inducer phosphatase 1
Type:Protein
Mol. Mass.:59090.18
Organism:Homo sapiens (Human)
Description:P30304
Residue:524
Sequence:
MELGPEPPHRRRLLFACSPPPASQPVVKALFGASAAGGLSPVTNLTVTMDQLQGLGSDYE
QPLEVKNNSNLQRMGSSESTDSGFCLDSPGPLDSKENLENPMRRIHSLPQKLLGCSPALK
RSHSDSLDHDIFQLIDPDENKENEAFEFKKPVRPVSRGCLHSHGLQEGKDLFTQRQNSAP
ARMLSSNERDSSEPGNFIPLFTPQSPVTATLSDEDDGFVDLLDGENLKNEEETPSCMASL
WTAPLVMRTTNLDNRCKLFDSPSLCSSSTRSVLKRPERSQEESPPGSTKRRKSMSGASPK
ESTNPEKAHETLHQSLSLASSPKGTIENILDNDPRDLIGDFSKGYLFHTVAGKHQDLKYI
SPEIMASVLNGKFANLIKEFVIIDCRYPYEYEGGHIKGAVNLHMEEEVEDFLLKKPIVPT
DGKRVIVVFHCEFSSERGPRMCRYVRERDRLGNEYPKLHYPELYVLKGGYKEFFMKCQSY
CEPPSYRPMHHEDFKEDLKKFRTKSRTWAGEKSKREMYSRLKKL
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50251709
NameBDBM50251709
Synonyms:CHEMBL4094844
TypeSmall organic molecule
Emp. Form.C17H8FNO3
Mol. Mass.293.2487
SMILESFc1ccc2[nH]c(=O)c3c4C(=O)C=CC(=O)c4ccc3c2c1 |c:12|
Structure
n/a