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TargetHuman immunodeficiency virus type 1 protease
LigandBDBM50006835
Substrate/Competitorn/a
Meas. Tech.ChEMBL_159304
IC50 63000±n/a nM
Citation Tucker, TJLumma, WCPayne, LSWai, JMde Solms, SJGiuliani, EADarke, PLHeimbach, JCZugay, JASchleif, WA A series of potent HIV-1 protease inhibitors containing a hydroxyethyl secondary amine transition state isostere: synthesis, enzyme inhibition, and antiviral activity. J Med Chem35:2525-33 (1992) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Human immunodeficiency virus type 1 protease
Name:Human immunodeficiency virus type 1 protease
Synonyms:Pol polyprotein
Type:Enzyme Subunit
Mol. Mass.:10781.16
Organism:Human immunodeficiency virus type 1
Description:n/a
Residue:99
Sequence:
PQVTLWQRPLVTIKIGGQLKEALLDTGADDTVLEEMSLPGRWKPKMIGGIGGFIKVRQYD
QILIEICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF
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BDBM50006835
NameBDBM50006835
Synonyms:2-(3-Amino-2-hydroxy-4-phenyl-butylamino)-N-(2-hydroxy-indan-1-yl)-3-phenyl-propionamide (0.25 hydrate) | CHEMBL313367
TypeSmall organic molecule
Emp. Form.C28H33N3O3
Mol. Mass.459.5799
SMILESN[C@@H](Cc1ccccc1)C(O)CN[C@@H](Cc1ccccc1)C(=O)NC1[C@H](O)Cc2ccccc12
Structure
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