Target
Folylpolyglutamate synthase, mitochondrial
Ligand
BDBM50006906
Substrate
n/a
Meas. Tech.
ChEBML_68805
Ki
67±n/a nM
Citation
 Rosowsky, AForsch, RAMoran, RG N-[4-[[(3,4-dihydro-4-oxo-1,2,3-benzotriazin-6- yl)methyl]amino]benzoyl]-L-glutamic acid, a novel A-ring analogue of 2-desamino-5,8-dideazafolic acid. J Med Chem 35:2626-30 (1992) [PubMed]  Article 
Target
Name:
Folylpolyglutamate synthase, mitochondrial
Synonyms:
FOLC_MOUSE | Folylpoly-gamma-glutamate synthetase | Folylpolyglutamate synthase, mitochondrial | Fpgs | Tetrahydrofolate synthase | Tetrahydrofolylpolyglutamate synthase
Type:
PROTEIN
Mol. Mass.:
64969.76
Organism:
Mus musculus
Description:
ChEMBL_68680
Residue:
587
Sequence:
MSWARSRLCSTLSLAAVSARGATTEGAARRGMSAWPAPQEPGMEYQDAVRTLNTLQTNASYLEQVKRQRSDPQAQLEAMEMYLARSGLQVEDLNRLNIIHVTGTKGKGSTCAFTERILRNYGLKTGFFSSPHMVQVRERIRINGKPISPELFTKHFWCLYNQLEEFKDDSHVSMPSYFRFLTLMAFHVFLQEKVDLAVVEVGIGGAFDCTNIIRKPVVCGVSSLGIDHTSLLGDTVEKIAWQKGGIFKPGVPAFTVVQPEGPLAVLRDRAQQIGCPLYLCPPLEALEEVGLPLSLGLEGAHQRSNAALALQLAHCWLERQDHQDIQELKVSRPSIRWQLPLAPVFRPTPHMRRGLRDTVWPGRTQILQRGPLTWYLDGAHTTSSVQACVHWYRQSLERSKRTDGGSEVHILLFNSTGDRDSAALLKLLQPCQFDYAVFCPNVTEVSSIGNADQQNFTVTLDQVLLRCLQHQQHWNGLAEKQASSNLWSSCGPDPAGPGSLLLAPHPPQPTRTSSLVFSCISHALLWISQGRDPIFQPQSLPRNLLNHPTANSGASILREAAAIHVLVTGSLHLVGGVLKLLDPSMSQ
  
Inhibitor
Name:
BDBM50006906
Synonyms:
2-{4-[(2-Amino-4-hydroxy-quinazolin-6-ylmethyl)-amino]-benzoylamino}-pentanedioic acid | 2-{4-[(2-Amino-4-hydroxy-quinazolin-6-ylmethyl)-methyl-amino]-benzoylamino}-pentanedioic acid 5-ethyl ester | 2-{4-[(2-Amino-4-oxo-3,4-dihydro-quinazolin-6-ylmethyl)-amino]-benzoylamino}-pentanedioic acid | CHEMBL23977
Type:
Small organic molecule
Emp. Form.:
C21H21N5O6
Mol. Mass.:
439.4213
SMILES:
Nc1nc2ccc(CNc3ccc(cc3)C(=O)NC(CCC(O)=O)C(O)=O)cc2c(=O)[nH]1
Structure:
Search PDB for entries with ligand similarity: