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Target
Mu-type opioid receptor
Ligand
BDBM50007332
Substrate
n/a
Meas. Tech.
ChEBML_146544
Ki
1.7±n/a nM
Citation
 Schiller, PW; Weltrowska, G; Nguyen, TM; Lemieux, C; Chung, NN; Marsden, BJ; Wilkes, BC Conformational restriction of the phenylalanine residue in a cyclic opioid peptide analogue: effects on receptor selectivity and stereospecificity. J Med Chem 34:3125-32 (1991) [PubMed]  Article 
Target
Name:
Mu-type opioid receptor
Synonyms:
MOR-1 | MUOR1 | Mu-type opioid receptor (MOR) | OPIATE Mu | OPRM_RAT | Opiate non-selective | Opioid receptor B | Oprm1 | Ror-b
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
44503.11
Organism:
Rattus norvegicus (rat)
Description:
Competition binding assays were carried out using membrane preparations from transfected HN9.10 cells that constitutively expressed the mu opioid receptor.
Residue:
398
Sequence:
MDSSTGPGNTSDCSDPLAQASCSPAPGSWLNLSHVDGNQSDPCGLNRTGLGGNDSLCPQTGSPSMVTAITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGTWPFGTILCKIVISIDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWYWENLLKICVFIFAFIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKALITIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCFREFCIPTSSTIEQQNSTRVRQNTREHPSTANTVDRTNHQLENLEAETAPLP
  
Inhibitor
Name:
BDBM50007332
Synonyms:
13-[2-Amino-3-(4-hydroxy-phenyl)-propionylamino]-3,8,14-trioxo-2-phenethyl-1,4,9triaza-cyclotetradecane-5-carboxylic acid amide | CHEMBL321335
Type:
Small organic molecule
Emp. Form.:
C29H38N6O6
Mol. Mass.:
566.6486
SMILES:
N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H]1CCCNC(=O)CC[C@H](NC(=O)[C@H](CCc2ccccc2)NC1=O)C(N)=O
Structure:
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