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Target
Platelet-activating factor receptor
Ligand
BDBM50007459
Substrate
n/a
Meas. Tech.
ChEBML_86450
IC50
1800±n/a nM
Citation
 Piwinski, JJ; Wong, JK; Green, MJ; Ganguly, AK; Billah, MM; West, RE; Kreutner, W Dual antagonists of platelet activating factor and histamine. Identification of structural requirements for dual activity of N-Acyl-4-(5,6-dihydro-11H-benzo [5,6]cyclohepta-[1,2-b]pyridin-11-ylidene)piperidines. J Med Chem 34:457-61 (1991) [PubMed]  Article 
Target
Name:
Platelet-activating factor receptor
Synonyms:
PAF Platelet activating factor | PAF-R | PAFR | PTAFR | PTAFR_HUMAN | Platelet activating factor receptor | Platelet-activating factor receptor
Type:
Enzyme Catalytic Domain
Mol. Mass.:
39219.60
Organism:
Homo sapiens (Human)
Description:
PAF Platelet activating factor PTAFR HUMAN::P25105
Residue:
342
Sequence:
MEPHDSSHMDSEFRYTLFPIVYSIIFVLGVIANGYVLWVFARLYPCKKFNEIKIFMVNLTMADMLFLITLPLWIVYYQNQGNWILPKFLCNVAGCLFFINTYCSVAFLGVITYNRFQAVTRPIKTAQANTRKRGISLSLVIWVAIVGAASYFLILDSTNTVPDSAGSGNVTRCFEHYEKGSVPVLIIHIFIVFSFFLVFLIILFCNLVIIRTLLMQPVQQQRNAEVKRRALWMVCTVLAVFIICFVPHHVVQLPWTLAELGFQDSKFHQAINDAHQVTLCLLSTNCVLDPVIYCFLTKKFRKHLTEKFYSMRSSRKCSRATTDTVTEVVVPFNQIPGNSLKN
  
Inhibitor
Name:
BDBM50007459
Synonyms:
1-[4-(8,9-Dichloro-5,6-dihydro-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-piperidin-1-yl]-ethanone | CHEMBL139760
Type:
Small organic molecule
Emp. Form.:
C21H20Cl2N2O
Mol. Mass.:
387.302
SMILES:
[#6]-[#6](=O)-[#7]-1-[#6]-[#6]\[#6](-[#6]-[#6]-1)=[#6]-1/c2cc(Cl)c(Cl)cc2-[#6]-[#6]-c2cccnc-12
Structure:
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