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Target
Histamine H1 receptor
Ligand
BDBM50007540
Substrate
n/a
Meas. Tech.
ChEBML_83771
IC50
430±n/a nM
Citation
 Sleevi, MC; Cale, AD; Gero, TW; Jaques, LW; Welstead, WJ; Johnson, AF; Kilpatrick, BF; Demian, I; Nolan, JC; Jenkins, H Optical isomers of rocastine and close analogues: synthesis and H1 antihistaminic activity of its enantiomers and their structural relationship to the classical antihistamines. J Med Chem 34:1314-28 (1991) [PubMed]  Article 
Target
Name:
Histamine H1 receptor
Synonyms:
HISTAMINE H1 | HRH1 | HRH1_CAVPO
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
55641.53
Organism:
Cavia porcellus (domestic guinea pig)
Description:
Guinea pig cerebellum was used in binding assay.
Residue:
488
Sequence:
MSFLPGMTPVTLSNFSWALEDRMLEGNSTTTPTRQLMPLVVVLSSVSLVTVALNLLVLYAVRSERKLHTVGNLYIVSLSVADLIVGAVVMPMSILYLHRSAWILGRPLCLFWLSMDYVASTASIFSVFILCIDRYRSVQQPLRYLRYRTKTRASATILGAWLLSFLWVIPILGWHHFMAPTSEPREKKCETDFYDVTWFKVMTAIINFYLPTLLMLWFYIRIYKAVRRHCQHRQLINSSLPSFSEMKLKLENAKVDTRRMGKESPWEDPKRCSKDASGVHTPMPSSQHLVDMPCAAVLSEDEGGEVGTRQMPMLAVGDGRCCEALNHMHSQLELSGQSRATHSISARPEEWTVVDGQSFPITDSDTSTEAAPMGGQPRSGSNSGLDYIKFTWRRLRSHSRQYTSGLHLNRERKAAKQLGCIMAAFILCWIPYFVFFMVIAFCKSCSNEPVHMFTIWLGYLNSTLNPLIYPLCNENFRKTFKRILRIPP
  
Inhibitor
Name:
BDBM50007540
Synonyms:
CHEMBL279907 | [3-(4-Chloro-phenyl)-3-(5-chloro-pyridin-2-yl)-propyl]-dimethyl-amine
Type:
Small organic molecule
Emp. Form.:
C16H18Cl2N2
Mol. Mass.:
309.234
SMILES:
CN(C)CCC(c1ccc(Cl)cc1)c1ccc(Cl)cn1
Structure:
Search PDB for entries with ligand similarity: