Reaction Details Report a problem with these data
Target
Sigma non-opioid intracellular receptor 1
Ligand
BDBM50007550
Substrate
n/a
Meas. Tech.
ChEMBL_201411 (CHEMBL810644)
Ki
800±n/a nM
Citation
 Froimowitz, M; Rämsby, S Conformational properties of semirigid antipsychotic drugs: the pharmacophore for dopamine D-2 antagonist activity. J Med Chem 34:1707-14 (1991) [PubMed]  Article 
Target
Name:
Sigma non-opioid intracellular receptor 1
Synonyms:
Aging-associated gene 8 protein | OPRS1 | SGMR1_HUMAN | SIG-1R | SIGMAR1 | SR-BP | SR31747-binding protein | SRBP | Sigma 1-type opioid receptor | Sigma opioid receptor | Sigma1R | hSigmaR1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
25124.85
Organism:
Homo sapiens (Human)
Description:
Q99720
Residue:
223
Sequence:
MQWAVGRRWAWAALLLAVAAVLTQVVWLWLGTQSFVFQREEIAQLARQYAGLDHELAFSRLIVELRRLHPGHVLPDEELQWVFVNAGGWMGAMCLLHASLSEYVLLFGTALGSRGHSGRYWAEISDTIISGTFHQWREGTTKSEVFYPGETVVHGPGEATAVEWGPNTWMVEYGRGVIPSTLAFALADTVFSTQDFLTLFYTLRSYARGLRLELTTYLFGQDP
  
Inhibitor
Name:
BDBM50007550
Synonyms:
3'-chlorospiro[2-cyclohexene-1,5'-(10',11'-dihydro-5'H-dibenzo[a,d]cycloheptene)]-4-yl(dimethyl)amine | CHEMBL300647 | Enantiomer 2'3'-chlorospiro[2-cyclohexene-1,5'-(10',11'-dihydro-5'H-dibenzo[a,d]cycloheptene)]-4-yl(dimethyl)amine
Type:
Small organic molecule
Emp. Form.:
C22H22ClN
Mol. Mass.:
335.87
SMILES:
CN(C)C1CCC2(C=C1)c1ccccc1C=Cc1ccc(Cl)cc21 |c:7,17|
Structure:
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