Reaction Details Report a problem with these data
Target
Dihydrofolate reductase
Ligand
BDBM50008285
Substrate
n/a
Meas. Tech.
ChEBML_54603
Ki
0.013000±n/a nM
Citation
DeGraw, JI; Christie, PH; Colwell, WT; Sirotnak, FM Synthesis and antifolate properties of 5,10-ethano-5,10-dideazaaminopterin. J Med Chem 35:320-4 (1992) [PubMed] Article
More Info.:
Target
Name:
Dihydrofolate reductase
Synonyms:
DYR_MOUSE | Dhfr
Type:
Enzyme
Mol. Mass.:
21608.82
Organism:
Mus musculus (Mouse)
Description:
n/a
Residue:
187
Sequence:
MVRPLNCIVAVSQNMGIGKNGDLPWPPLRNEFKYFQRMTTTSSVEGKQNLVIMGRKTWFSIPEKNRPLKDRINIVLSRELKEPPRGAHFLAKSLDDALRLIEQPELASKVDMVWIVGGSSVYQEAMNQPGHLRLFVTRIMQEFESDTFFPEIDLGKYKLLPEYPGVLSEVQEEKGIKYKFEVYEKKD