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Target
Aldo-keto reductase family 1 member B1
Ligand
BDBM50008437
Substrate
n/a
Meas. Tech.
ChEBML_31764
IC50
1100±n/a nM
Citation
 Mylari, BL; Beyer, TA; Scott, PJ; Aldinger, CE; Dee, MF; Siegel, TW; Zembrowski, WJ Potent, orally active aldose reductase inhibitors related to zopolrestat: surrogates for benzothiazole side chain. J Med Chem 35:457-65 (1992) [PubMed]  Article 
Target
Name:
Aldo-keto reductase family 1 member B1
Synonyms:
AKR1B1 | ALDR1 | ALDR_HUMAN | ALR2 | AR | Aldo-keto reductase family 1 member B1 (AKR1B1) | Aldose Reductase (ALR2) | Aldose reductase | Aldose reductase (AR)
Type:
Protein
Mol. Mass.:
35855.50
Organism:
Homo sapiens (Human)
Description:
P15121. 4LAU; 2IKI; 4LB4; 2FZD; 2FZ8; 1US0
Residue:
316
Sequence:
MASRLLLNNGAKMPILGLGTWKSPPGQVTEAVKVAIDVGYRHIDCAHVYQNENEVGVAIQEKLREQVVKREELFIVSKLWCTYHEKGLVKGACQKTLSDLKLDYLDLYLIHWPTGFKPGKEFFPLDESGNVVPSDTNILDTWAAMEELVDEGLVKAIGISNFNHLQVEMILNKPGLKYKPAVNQIECHPYLTQEKLIQYCQSKGIVVTAYSPLGSPDRPWAKPEDPSLLEDPRIKAIAAKHNKTTAQVLIRFPMQRNLVVIPKSVTPERIAENFKVFDFELSSQDMTTLLSYNRNWRVCALLSCTSHKDYPFHEEF
  
Inhibitor
Name:
BDBM50008437
Synonyms:
CHEMBL356789 | {3-[(3,5-Bis-trifluoromethyl-phenylcarbamoyl)-methyl]-4-oxo-3,4-dihydro-phthalazin-1-yl}-acetic acid
Type:
Small organic molecule
Emp. Form.:
C20H13F6N3O4
Mol. Mass.:
473.3253
SMILES:
OC(=O)Cc1nn(CC(=O)Nc2cc(cc(c2)C(F)(F)F)C(F)(F)F)c(=O)c2ccccc12
Structure:
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