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Target
Neprilysin
Ligand
BDBM50008608
Substrate
n/a
Meas. Tech.
ChEBML_64516
IC50
150±n/a nM
Citation
 Mimura, T; Nakamura, Y; Nishino, J; Sawayama, T; Komiya, T; Deguchi, T; Kita, A; Nakamura, H; Matsumoto, J A novel class of enkephalinase inhibitors containing a C-terminal sulfo group. J Med Chem 35:602-8 (1992) [PubMed]  Article 
Target
Name:
Neprilysin
Synonyms:
Mme | NEP_RAT | Neprilysin | Neutral Endopeptidase (NEP) | Neutral endopeptidase 24.11
Type:
Protein
Mol. Mass.:
85789.59
Organism:
Rattus norvegicus (Rat)
Description:
P07861
Residue:
750
Sequence:
MGRSESQMDITDINAPKPKKKQRWTPLEISLSVLVLLLTIIAVTMIALYATYDDGICKSSDCIKSAARLIQNMDASAEPCTDFFKYACGGWLKRNVIPETSSRYSNFDILRDELEVILKDVLQEPKTEDIVAVQKAKTLYRSCINESAIDSRGGQPLLTLLPDIYGWPVASQNWEQTYGTSWTAEKSIAQLNSKYGKKVLINFFVGTDDKNSTQHIIHFDQPRLGLPSRDYYECTGIYKEACTAYVDFMISVARLIRQEQRLPIDENQLSLEMNKVMELEKEIANATTKPEDRNDPMLLYNKMTLAKLQNNFSLEINGKPFSWSNFTNEIMSTVNINIQNEEEVVVYAPEYLTKLKPILTKYSPRDLQNLMSWRFIMDLVSSLSRNYKESRNAFRKALYGTTSETATWRRCANYVNGNMENAVGRLYVEAAFAGESKHVVEDLIAQIREVFIQTLDDLTWMDAETKKKAEEKALAIKERIGYPDDIISNENKLNNEYLELNYKEEEYFENIIQNLKFSQSKQLKKLREKVDKDEWISGAAVVNAFYSSGRNQIVFPAGILQPPFFSARQSNSLNYGGIGMVIGHEITHGFDDNGRNFNKDGDLVDWWTQQSANNFKDQSQCMVYQYGNFTWDLAGGQHLNGINTLGENIADNGGIGQAYRAYQNYVKKNGEEKLLPGLDLNHKQLFFLNFAQVWCGTYRPEYAVNSIKTDVHSPGNFRIIGTLQNSAEFADAFHCRKNSYMNPERKCRVW
  
Inhibitor
Name:
BDBM50008608
Synonyms:
CHEMBL154790 | Sodium; 4-[2-mercaptomethyl-3-(4-trifluoromethyl-phenyl)-propionylamino]-benzenesulfonate (0.25H2O)
Type:
Small organic molecule
Emp. Form.:
C17H15F3NO4S2
Mol. Mass.:
418.431
SMILES:
[O-]S(=O)(=O)c1ccc(NC(=O)C(CS)Cc2ccc(cc2)C(F)(F)F)cc1
Structure:
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