Reaction Details Report a problem with these data
Target
Renin
Ligand
BDBM50009900
Substrate
n/a
Meas. Tech.
ChEBML_192728
IC50
3.3±n/a nM
Citation
Doherty, AM; Kaltenbronn, JS; Hudspeth, JP; Repine, JT; Roark, WH; Sircar, I; Tinney, FJ; Connolly, CJ; Hodges, JC; Taylor, MD New inhibitors of human renin that contain novel replacements at the P2 site. J Med Chem 34:1258-71 (1991) [PubMed] Article
More Info.:
Target
Name:
Renin
Synonyms:
Angiotensinogenase | REN | RENI_HUMAN
Type:
Enzyme
Mol. Mass.:
45058.99
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
406
Sequence:
MDGWRRMPRWGLLLLLWGSCTFGLPTDTTTFKRIFLKRMPSIRESLKERGVDMARLGPEWSQPMKRLTLGNTTSSVILTNYMDTQYYGEIGIGTPPQTFKVVFDTGSSNVWVPSSKCSRLYTACVYHKLFDASDSSSYKHNGTELTLRYSTGTVSGFLSQDIITVGGITVTQMFGEVTEMPALPFMLAEFDGVVGMGFIEQAIGRVTPIFDNIISQGVLKEDVFSFYYNRDSENSQSLGGQIVLGGSDPQHYEGNFHYINLIKTGVWQIQMKGVSVGSSTLLCEDGCLALVDTGASYISGSTSSIEKLMEALGAKKRLFDYVVKCNEGPTLPDISFHLGGKEYTLTSADYVFQESYSSKKLCTLAIHAMDIPPPTGPTWALGATFIRKFYTEFDRRNNRIGFALAR
Inhibitor
Name:
BDBM50009900
Synonyms:
CHEMBL23944 | {5-{4-[2-(2-Amino-ethyl)-morpholin-4-yl]-3,3-difluoro-1-isobutyl-2,4-dioxo-butylcarbamoyl}-5-[2-(morpholine-4-sulfonylamino)-3-phenyl-propionylamino]-pentyl}-carbamic acid benzyl ester
Type:
Small organic molecule
Emp. Form.:
C41H59F2N7O10S
Mol. Mass.:
880.01
SMILES:
CC(C)CC(NC(=O)C(CCCCNC(=O)OCc1ccccc1)NC(=O)C(Cc1ccccc1)NS(=O)(=O)N1CCOCC1)C(=O)C(F)(F)C(=O)N1CCOC(CCN)C1