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TargetAldose reductase (ALR2)
LigandBDBM16312
Substrate/Competitorn/a
Meas. Tech.ChEMBL_31340
IC50 1100±n/a nM
Citation Wrobel, JMillen, JSredy, JDietrich, AGorham, BJMalamas, MKelly, JMBauman, JGHarrison, MCJones, LR Syntheses of tolrestat analogues containing additional substituents in the ring and their evaluation as aldose reductase inhibitors. Identification of potent, orally active 2-fluoro derivatives. J Med Chem34:2504-20 (1991) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Aldose reductase (ALR2)
Name:Aldose reductase
Synonyms:Aldose reductase
Type:Protein
Mol. Mass.:35916.27
Organism:Bos taurus (Cattle)
Description:n/a
Residue:315
Sequence:
AHNIVLYTGAKMPILGLGTWKSPPGKVTEAVKVAIDLGYRHIDCAHVYQNENEVGLALQA
KLQEQVVKREDLFIVSKLWCTYHDKDLVKGACQKTLSDLKLDYLDLYLIHWPTGFKPGKD
FFPLDEDGNVIPSEKDFVDTWTAMEELVDEGLVKAIGVSNFNHLQVEKILNKPGLKYKPA
VNQIECHPYLTQEKLIQYCNSKGIVVTAYSPLGSPDRPWAKPEDPSILEDPRIKAIADKY
NKTTAQVLIRFPIQRNLIVIPKSVTPERIAENFQVFDFELDKEDMNTLLSYNRDWRACAL
VSCASHRDYPFHEEF
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM16312
NameBDBM16312
Synonyms:(4S)-6-fluoro-2,3-dihydrospiro[1-benzopyran-4,4'-imidazolidine]-2',5'-dione | CHEMBL266497 | Sorbinil
TypeSmall organic molecule
Emp. Form.C11H9FN2O3
Mol. Mass.236.1992
SMILESFc1ccc2OCC[C@]3(NC(=O)NC3=O)c2c1 |r|
Structure
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n/a