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TargetAldose reductase (ALR2)
LigandBDBM50010062
Substrate/Competitorn/a
Meas. Tech.ChEMBL_31457
IC50 25±n/a nM
Citation Wrobel, JMillen, JSredy, JDietrich, AGorham, BJMalamas, MKelly, JMBauman, JGHarrison, MCJones, LR Syntheses of tolrestat analogues containing additional substituents in the ring and their evaluation as aldose reductase inhibitors. Identification of potent, orally active 2-fluoro derivatives. J Med Chem34:2504-20 (1991) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Aldose reductase (ALR2)
Name:Aldose reductase
Synonyms:Aldose reductase
Type:Protein
Mol. Mass.:35916.27
Organism:Bos taurus (Cattle)
Description:n/a
Residue:315
Sequence:
AHNIVLYTGAKMPILGLGTWKSPPGKVTEAVKVAIDLGYRHIDCAHVYQNENEVGLALQA
KLQEQVVKREDLFIVSKLWCTYHDKDLVKGACQKTLSDLKLDYLDLYLIHWPTGFKPGKD
FFPLDEDGNVIPSEKDFVDTWTAMEELVDEGLVKAIGVSNFNHLQVEKILNKPGLKYKPA
VNQIECHPYLTQEKLIQYCNSKGIVVTAYSPLGSPDRPWAKPEDPSILEDPRIKAIADKY
NKTTAQVLIRFPIQRNLIVIPKSVTPERIAENFQVFDFELDKEDMNTLLSYNRDWRACAL
VSCASHRDYPFHEEF
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  Blast E-value cutoff:
BDBM50010062
NameBDBM50010062
Synonyms:CHEMBL84152 | [(2-Fluoro-6-methoxy-5-trifluoromethyl-naphthalene-1-carbonyl)-methoxycarbonyl-amino]-acetic acid
TypeSmall organic molecule
Emp. Form.C17H13F4NO6
Mol. Mass.403.2818
SMILESCOC(=O)N(CC(O)=O)C(=O)c1c(F)ccc2c(c(OC)ccc12)C(F)(F)F
Structure
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n/a