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Target
Histamine H3 receptor
Ligand
BDBM22886
Substrate
n/a
Meas. Tech.
ChEMBL_86895 (CHEMBL698405)
Ki
60±n/a nM
Citation
 Timmerman, H Histamine H3 ligands: just pharmacological tools or potential therapeutic agents? J Med Chem 33:4-11 (1990) [PubMed]  Article 
Target
Name:
Histamine H3 receptor
Synonyms:
HH3R | HRH3_RAT | Hrh3
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
48607.98
Organism:
Rattus norvegicus (rat)
Description:
n/a
Residue:
445
Sequence:
MERAPPDGLMNASGTLAGEAAAAGGARGFSAAWTAVLAALMALLIVATVLGNALVMLAFVADSSLRTQNNFFLLNLAISDFLVGAFCIPLYVPYVLTGRWTFGRGLCKLWLVVDYLLCASSVFNIVLISYDRFLSVTRAVSYRAQQGDTRRAVRKMALVWVLAFLLYGPAILSWEYLSGGSSIPEGHCYAEFFYNWYFLITASTLEFFTPFLSVTFFNLSIYLNIQRRTRLRLDGGREAGPEPPPDAQPSPPPAPPSCWGCWPKGHGEAMPLHRYGVGEAGPGVEAGEAALGGGSGGGAAASPTSSSGSSSRGTERPRSLKRGSKPSASSASLEKRMKMVSQSITQRFRLSRDKKVAKSLAIIVSIFGLCWAPYTLLMIIRAACHGRCIPDYWYETSFWLLWANSAVNPVLYPLCHYSFRRAFTKLLCPQKLKVQPHGSLEQCWK
  
Inhibitor
Name:
BDBM22886
Synonyms:
3-[(2R)-1-(1H-imidazol-5-yl)propan-2-yl]-2-(2-{[(5-methyl-1H-imidazol-4-yl)methyl]sulfanyl}ethyl)guanidine | CHEMBL275803 | N-[2-(1H-Imidazol-4-yl)-1-methyl-ethyl]-N'-[2-(5-methyl-1H-imidazol-4-ylmethylsulfanyl)-ethyl]-guanidine(R-sopromidine) | R-(-)-Sopromidine
Type:
Small organic molecule
Emp. Form.:
C14H23N7S
Mol. Mass.:
321.444
SMILES:
C[C@H](Cc1cnc[nH]1)N=C(N)NCCSCc1[nH]cnc1C |w:9.10|
Structure:
Search PDB for entries with ligand similarity: