Reaction Details Report a problem with these data
Target
Folylpolyglutamate synthase, mitochondrial
Ligand
BDBM50010929
Substrate
n/a
Meas. Tech.
ChEBML_68517
IC50
>200000±n/a nM
Citation
 Abraham, A; McGuire, JJ; Galivan, J; Nimec, Z; Kisliuk, RL; Gaumont, Y; Nair, MG Folate analogues. 34. Synthesis and antitumor activity of non-polyglutamylatable inhibitors of dihydrofolate reductase. J Med Chem 34:222-7 (1991) [PubMed]  Article 
Target
Name:
Folylpolyglutamate synthase, mitochondrial
Synonyms:
FOLC_HUMAN | FPGS | Folylpoly-gamma-glutamate synthetase | Folylpolyglutamate synthase, mitochondrial | Tetrahydrofolate synthase | Tetrahydrofolylpolyglutamate synthase
Type:
PROTEIN
Mol. Mass.:
64621.95
Organism:
Homo sapiens (Human)
Description:
ChEMBL_68676
Residue:
587
Sequence:
MSRARSHLRAALFLAAASARGITTQVAARRGLSAWPVPQEPSMEYQDAVRMLNTLQTNAGYLEQVKRQRGDPQTQLEAMELYLARSGLQVEDLDRLNIIHVTGTKGKGSTCAFTECILRSYGLKTGFFSSPHLVQVRERIRINGQPISPELFTKYFWRLYHRLEETKDGSCVSMPPYFRFLTLMAFHVFLQEKVDLAVVEVGIGGAYDCTNIIRKPVVCGVSSLGIDHTSLLGDTVEKIAWQKGGIFKQGVPAFTVLQPEGPLAVLRDRAQQISCPLYLCPMLEALEEGGPPLTLGLEGEHQRSNAALALQLAHCWLQRQDRHGAGEPKASRPGLLWQLPLAPVFQPTSHMRLGLRNTEWPGRTQVLRRGPLTWYLDGAHTASSAQACVRWFRQALQGRERPSGGPEVRVLLFNATGDRDPAALLKLLQPCQFDYAVFCPNLTEVSSTGNADQQNFTVTLDQVLLRCLEHQQHWNHLDEEQASPDLWSAPSPEPGGSASLLLAPHPPHTCSASSLVFSCISHALQWISQGRDPIFQPPSPPKGLLTHPVAHSGASILREAAAIHVLVTGSLHLVGGVLKLLEPALSQ
  
Inhibitor
Name:
BDBM50010929
Synonyms:
2-{4-[2-(2,4-Diamino-pteridin-6-yl)-ethyl]-benzoylamino}-4-methylene-pentanedioic acid | CHEMBL307486
Type:
Small organic molecule
Emp. Form.:
C21H21N7O5
Mol. Mass.:
451.4353
SMILES:
Nc1nc(N)c2nc(CCc3ccc(cc3)C(=O)NC(CC(=C)C(O)=O)C(O)=O)cnc2n1
Structure:
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