Reaction Details Report a problem with these data
Target
ERO1-like protein alpha
Ligand
BDBM50265447
Substrate
n/a
Meas. Tech.
ChEMBL_1699786 (CHEMBL4050768)
IC50
1900±n/a nM
Citation
 Geldenhuys, WJ; Bergeron, SA; Mullins, JE; Aljammal, R; Gaasch, BL; Chen, WC; Yun, J; Hazlehurst, LA High-content screen using zebrafish (Danio rerio) embryos identifies a novel kinase activator and inhibitor. Bioorg Med Chem Lett 27:2029-2037 (2017) [PubMed]  Article 
Target
Name:
ERO1-like protein alpha
Synonyms:
1.8.4.- | ERO1-L | ERO1-L-alpha | ERO1-like protein alpha | ERO1A_MOUSE | Endoplasmic reticulum oxidoreductase alpha | Endoplasmic reticulum oxidoreductin-1-like protein | Ero1a | Ero1l | Oxidoreductin-1-L-alpha
Type:
PROTEIN
Mol. Mass.:
54083.82
Organism:
Mus musculus
Description:
ChEMBL_117454
Residue:
464
Sequence:
MGRAWGLLVGLLGVVWLLRLGHGEERRPETAAQRCFCQVSGYLDDCTCDVETIDKFNNYRLFPRLQKLLESDYFRYYKVNLKKPCPFWNDINQCGRRDCAVKPCHSDEVPDGIKSASYKYSEEANRIEECEQAERLGAVDESLSEETQKAVLQWTKHDDSSDSFCEIDDIQSPDAEYVDLLLNPERYTGYKGPDAWRIWSVIYEENCFKPQTIQRPLASGRGKSKENTFYNWLEGLCVEKRAFYRLISGLHASINVHLSARYLLQDTWLEKKWGHNVTEFQQRFDGILTEGEGPRRLRNLYFLYLIELRALSKVLPFFERPDFQLFTGNKVQDAENKALLLEILHEIKSFPLHFDENSFFAGDKNEAHKLKEDFRLHFRNISRIMDCVGCFKCRLWGKLQTQGLGTALKILFSEKLIANMPESGPSYEFQLTRQEIVSLFNAFGRISTSVRELENFRHLLQNVH
  
Inhibitor
Name:
BDBM50265447
Synonyms:
CHEMBL4060344
Type:
Small organic molecule
Emp. Form.:
C24H14ClF3O4
Mol. Mass.:
458.814
SMILES:
OC(=O)c1cc(ccc1Cl)C1C=C(\C(=C\c2ccc(o2)-c2ccccc2)C1=O)C(F)(F)F |c:12|
Structure:
Search PDB for entries with ligand similarity: