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Target
Tyrosine-protein phosphatase non-receptor type 7
Ligand
BDBM50272020
Substrate
n/a
Meas. Tech.
ChEMBL_1711905 (CHEMBL4121954)
IC50
250±n/a nM
Citation
 Korntner, S; Pomorski, A; Kr??el, A; Bishop, AC Optimized allosteric inhibition of engineered protein tyrosine phosphatases with an expanded palette of biarsenical small molecules. Bioorg Med Chem 26:2610-2620 (2018) [PubMed]  Article 
Target
Name:
Tyrosine-protein phosphatase non-receptor type 7
Synonyms:
He-PTP | Hematopoietic protein-tyrosine phosphatase | Hematopoietic protein-tyrosine phosphatase (HEPTP) | PTN7_HUMAN | PTPN7 | Protein-tyrosine phosphatase LC-PTP | Tyrosine-protein phosphatase non-receptor type 7 | Tyrosine-protein phosphatase non-receptor type 7 (HEPTP)
Type:
Protein
Mol. Mass.:
40530.79
Organism:
Homo sapiens (Human)
Description:
P35236
Residue:
360
Sequence:
MVQAHGGRSRAQPLTLSLGAAMTQPPPEKTPAKKHVRLQERRGSNVALMLDVRSLGAVEPICSVNTPREVTLHFLRTAGHPLTRWALQRQPPSPKQLEEEFLKIPSNFVSPEDLDIPGHASKDRYKTILPNPQSRVCLGRAQSQEDGDYINANYIRGYDGKEKVYIATQGPMPNTVSDFWEMVWQEEVSLIVMLTQLREGKEKCVHYWPTEEETYGPFQIRIQDMKECPEYTVRQLTIQYQEERRSVKHILFSAWPDHQTPESAGPLLRLVAEVEESPETAAHPGPIVVHCSAGIGRTGCFIATRIGCQQLKARGEVDILGIVCQLRLDRGGMIQTAEQYQFLHHTLALYAGQLPEEPSP
  
Inhibitor
Name:
BDBM50272020
Synonyms:
CHEBI:52107 | CHEMBL454668
Type:
Small organic molecule
Emp. Form.:
C24H18As2O5S4
Mol. Mass.:
664.5
SMILES:
n/a
Structure:
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