Reaction Details Report a problem with these data
Target
Tumor necrosis factor
Ligand
BDBM60918
Substrate
n/a
Meas. Tech.
ChEMBL_1715329 (CHEMBL4125378)
IC50
20600000±n/a nM
Citation
 Kadayat, TM; Banskota, S; Bist, G; Gurung, P; Magar, TBT; Shrestha, A; Kim, JA; Lee, ES Synthesis and biological evaluation of pyridine-linked indanone derivatives: Potential agents for inflammatory bowel disease. Bioorg Med Chem Lett 28:2436-2441 (2018) [PubMed]  Article 
Target
Name:
Tumor necrosis factor
Synonyms:
Cachectin | TNF | TNF-a | TNF-alpha | TNFA | TNFA_HUMAN | TNFSF2 | Tumor necrosis factor (TNF-alpha) | Tumor necrosis factor (TNFa) | Tumor necrosis factor alpha (TNFα) | Tumor necrosis factor ligand superfamily member 2 | Tumor necrosis factor, membrane form | Tumor necrosis factor, soluble form | tumor necrosis factor alpha
Type:
Enzyme
Mol. Mass.:
25645.11
Organism:
Homo sapiens (Human)
Description:
P01375
Residue:
233
Sequence:
MSTESMIRDVELAEEALPKKTGGPQGSRRCLFLSLFSFLIVAGATTLFCLLHFGVIGPQREEFPRDLSLISPLAQAVRSSSRTPSDKPVAHVVANPQAEGQLQWLNRRANALLANGVELRDNQLVVPSEGLYLIYSQVLFKGQGCPSTHVLLTHTISRIAVSYQTKVNLLSAIKSPCQRETPEGAEAKPWYEPIYLGGVFQLEKGDRLSAEINRPDYLDFAESGQVYFGIIAL
  
Inhibitor
Name:
BDBM60918
Synonyms:
5-Amino-2-hydroxy-benzoic acid | MESALAMINE | MLS001424012 | SMR000145728 | cid_4075
Type:
Small organic molecule
Emp. Form.:
C7H7NO3
Mol. Mass.:
153.1354
SMILES:
Nc1ccc(O)c(c1)C(O)=O
Structure:
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