| Reaction Details |
|---|
 | Report a problem with these data |
| Target | 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMG-CoA) |
|---|
| Ligand | BDBM50014822 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEBML_80478 |
|---|
| IC50 | 150±n/a nM |
|---|
| Citation |  Beck, G; Kesseler, K; Baader, E; Bartmann, W; Bergmann, A; Granzer, E; Jendralla, H; von Kerekjarto, B; Krause, R; Paulus, E Synthesis and biological activity of new HMG-CoA reductase inhibitors. 1. Lactones of pyridine- and pyrimidine-substituted 3,5-dihydroxy-6-heptenoic (-heptanoic) acids. J Med Chem33:52-60 (1990) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMG-CoA) |
|---|
| Name: | HMG-CoA reductase |
|---|
| Synonyms: | 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase | HMG-CoA Reductase | HMG-CoA reductase (HMGR) |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 97477.10 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P04035 |
|---|
| Residue: | 888 |
|---|
| Sequence: | MLSRLFRMHGLFVASHPWEVIVGTVTLTICMMSMNMFTGNNKICGWNYECPKFEEDVLSS
DIIILTITRCIAILYIYFQFQNLRQLGSKYILGIAGLFTIFSSFVFSTVVIHFLDKELTG
LNEALPFFLLLIDLSRASTLAKFALSSNSQDEVRENIARGMAILGPTFTLDALVECLVIG
VGTMSGVRQLEIMCCFGCMSVLANYFVFMTFFPACVSLVLELSRESREGRPIWQLSHFAR
VLEEEENKPNPVTQRVKMIMSLGLVLVHAHSRWIADPSPQNSTADTSKVSLGLDENVSKR
IEPSVSLWQFYLSKMISMDIEQVITLSLALLLAVKYIFFEQTETESTLSLKNPITSPVVT
QKKVPDNCCRREPMLVRNNQKCDSVEEETGINRERKVEVIKPLVAETDTPNRATFVVGNS
SLLDTSSVLVTQEPEIELPREPRPNEECLQILGNAEKGAKFLSDAEIIQLVNAKHIPAYK
LETLMETHERGVSIRRQLLSKKLSEPSSLQYLPYRDYNYSLVMGACCENVIGYMPIPVGV
AGPLCLDEKEFQVPMATTEGCLVASTNRGCRAIGLGGGASSRVLADGMTRGPVVRLPRAC
DSAEVKAWLETSEGFAVIKEAFDSTSRFARLQKLHTSIAGRNLYIRFQSRSGDAMGMNMI
SKGTEKALSKLHEYFPEMQILAVSGNYCTDKKPAAINWIEGRGKSVVCEAVIPAKVVREV
LKTTTEAMIEVNINKNLVGSAMAGSIGGYNAHAANIVTAIYIACGQDAAQNVGSSNCITL
MEASGPTNEDLYISCTMPSIEIGTVGGGTNLLPQQACLQMLGVQGACKDNPGENARQLAR
IVCGTVMAGELSLMAALAAGHLVKSHMIHNRSKINLQDLQGACTKKTA
|
|
|
|---|
| BDBM50014822 |
|---|
| Name | BDBM50014822 |
|---|
| Synonyms: | (E)-4-Hydroxy-6-{2-[2-isopropyl-4-(4-methoxy-phenyl)-6-phenyl-pyridin-3-yl]-vinyl}-tetrahydro-pyran-2-one | CHEMBL2368194 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C28H29NO4 |
|---|
| Mol. Mass. | 443.5342 |
|---|
| SMILES | COc1ccc(cc1)-c1cc(nc(C(C)C)c1\C=C\[C@@H]1C[C@@H](O)CC(=O)O1)-c1ccccc1 |
|---|
| Structure | 
|
|---|
| n/a |
|---|
Search and Browse
