Reaction Details Report a problem with these data
Target
Cystathionine gamma-lyase
Ligand
BDBM50280012
Substrate
n/a
Meas. Tech.
ChEBML_1721616
IC50
6000±n/a nM
Citation
 Bhattacharjee, A; Sinha, A; Ratia, K; Yin, L; Delgado-Rivera, L; Petukhov, PA; Thatcher, GRJ; Wardrop, DJ 2-Arylidene Hydrazinecarbodithioates as Potent, Selective Inhibitors of Cystathionine ?-Lyase (CSE). ACS Med Chem Lett 8:1241-1245 (2017) [PubMed]  Article 
Target
Name:
Cystathionine gamma-lyase
Synonyms:
CGL_HUMAN | CTH | Cystathionine gamma-lyase (CSE) | Cysteine-protein sulfhydrase | Gamma-cystathionase
Type:
Protein
Mol. Mass.:
44509.52
Organism:
Homo sapiens (Human)
Description:
P32929
Residue:
405
Sequence:
MQEKDASSQGFLPHFQHFATQAIHVGQDPEQWTSRAVVPPISLSTTFKQGAPGQHSGFEYSRSGNPTRNCLEKAVAALDGAKYCLAFASGLAATVTITHLLKAGDQIICMDDVYGGTNRYFRQVASEFGLKISFVDCSKIKLLEAAITPETKLVWIETPTNPTQKVIDIEGCAHIVHKHGDIILVVDNTFMSPYFQRPLALGADISMYSATKYMNGHSDVVMGLVSVNCESLHNRLRFLQNSLGAVPSPIDCYLCNRGLKTLHVRMEKHFKNGMAVAQFLESNPWVEKVIYPGLPSHPQHELVKRQCTGCTGMVTFYIKGTLQHAEIFLKNLKLFTLAESLGGFESLAELPAIMTHASVLKNDRDVLGISDTLIRLSVGLEDEEDLLEDLDQALKAAHPPSGSHS
  
Inhibitor
Name:
BDBM50280012
Synonyms:
CHEMBL4174491
Type:
Small organic molecule
Emp. Form.:
C16H12F4N4OS2
Mol. Mass.:
416.416
SMILES:
Fc1cccnc1\C=N\NC(=S)SCC(=O)Nc1ccc(cc1)C(F)(F)F
Structure:
Search PDB for entries with ligand similarity: