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Target
Dihydrofolate reductase
Ligand
BDBM50016461
Substrate
n/a
Meas. Tech.
ChEMBL_55081 (CHEMBL663894)
IC50
20±n/a nM
Citation
 Nair, MG; Nanavati, NT; Kumar, P; Gaumont, Y; Kisliuk, RL Synthesis and biological evaluation of poly-gamma-glutamyl metabolites of 10-deazaaminopterin and 10-ethyl-10-deazaaminopterin. J Med Chem 31:181-5 (1988) [PubMed]  Article 
Target
Name:
Dihydrofolate reductase
Synonyms:
DYR_LACCA | dhfR | folA
Type:
PROTEIN
Mol. Mass.:
18437.08
Organism:
Lactobacillus casei
Description:
ChEMBL_1357878
Residue:
163
Sequence:
MTAFLWAQDRDGLIGKDGHLPWHLPDDLHYFRAQTVGKIMVVGRRTYESFPKRPLPERTNVVLTHQEDYQAQGAVVVHDVAAVFAYAKQHPDQELVIAGGAQIFTAFKDDVDTLLVTRLAGSFEGDTKMIPLNWDDFTKVSSRTVEDTNPALTHTYEVWQKKA
  
Inhibitor
Name:
BDBM50016461
Synonyms:
(S)-2-{4-[2-(2,4-Diamino-pteridin-6-yl)-ethyl]-benzoylamino}-pentanedioic acid | CHEMBL293263 | GNF-PF-173
Type:
Small organic molecule
Emp. Form.:
C20H21N7O5
Mol. Mass.:
439.4246
SMILES:
Nc1nc(N)c2nc(CCc3ccc(cc3)C(=O)N[C@@H](CCC(O)=O)C(O)=O)cnc2n1
Structure:
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