Reaction Details Report a problem with these data
Target
Aldo-keto reductase family 1 member B1
Ligand
BDBM50009999
Substrate
n/a
Meas. Tech.
ChEMBL_32074 (CHEMBL645985)
IC50
330000±n/a nM
Citation
 DeRuiter, J; Swearingen, BE; Wandrekar, V; Mayfield, CA Synthesis and in vitro aldose reductase inhibitory activity of compounds containing an N-acylglycine moiety. J Med Chem 32:1033-8 (1989) [PubMed]  Article 
Target
Name:
Aldo-keto reductase family 1 member B1
Synonyms:
ALDR_RAT | Akr1b1 | Akr1b4 | Aldose reductase | Aldr1
Type:
PROTEIN
Mol. Mass.:
35797.87
Organism:
Rattus norvegicus
Description:
ChEMBL_1512484
Residue:
316
Sequence:
MASHLELNNGTKMPTLGLGTWKSPPGQVTEAVKVAIDMGYRHIDCAQVYQNEKEVGVALQEKLKEQVVKRQDLFIVSKLWCTFHDQSMVKGACQKTLSDLQLDYLDLYLIHWPTGFKPGPDYFPLDASGNVIPSDTDFVDTWTAMEQLVDEGLVKAIGVSNFNPLQIERILNKPGLKYKPAVNQIECHPYLTQEKLIEYCHCKGIVVTAYSPLGSPDRPWAKPEDPSLLEDPRIKEIAAKYNKTTAQVLIRFPIQRNLVVIPKSVTPARIAENFKVFDFELSNEDMATLLSYNRNWRVCALMSCAKHKDYPFHAEV
  
Inhibitor
Name:
BDBM50009999
Synonyms:
CHEMBL461 | N-benzoylglycine
Type:
Small organic molecule
Emp. Form.:
C9H9NO3
Mol. Mass.:
179.1727
SMILES:
OC(=O)CNC(=O)c1ccccc1
Structure:
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