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TargetNeuraminidase
LigandBDBM50294412
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1731956
IC50 940±n/a nM
Citation Ju, HZhang, JSun, ZHuang, ZQi, WHuang, BZhan, PLiu, X Discovery of C-1 modified oseltamivir derivatives as potent influenza neuraminidase inhibitors. Eur J Med Chem146:220-231 (2018) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Neuraminidase
Name:Neuraminidase
Synonyms:n/a
Type:PROTEIN
Mol. Mass.:49673.59
Organism:Influenza A virus
Description:ChEMBL_1347422
Residue:453
Sequence:
MNPNQKIITIGSICMVVGIISLILQIGNIISIWISHSIQTGNQNHTGICNQGSITYKVVA
GQDSTSVILTGNSSLCPIRGWAIHSKDNGIRIGSKGDVFVIREPFISCSHLECRTFFLTQ
GALLNDKHSRGTFKDRSPYRALMSCPVGEAPSPYNSRFESVAWSASACHDGMGWLTIGIS
GPDDGAVAVLKYNGIITETIKSWRKNILRTQESECTCVNGSCFTIMTDGPSDGLASYKIF
KIEKGKVTKSIELNAPNSHYEECSCYPDTGKVMCVCRDNWHGSNRPWVSFDQNLDYKIGY
ICSGVFGDNPRPKDGTGSCGPVSADGANGVKGFSYKYGNGVWIGRTKSDSSRHGFEMIWD
PNGWTETDSRFSMRQDVVAMTDRSGYSGSFVQHPELTGLDCMRPCFWVELIRGLPEENAI
WTSGSIISFCGVNSDTVDWSWPDGAELPFTIDK
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50294412
NameBDBM50294412
Synonyms:CHEMBL4164663
TypeSmall organic molecule
Emp. Form.C21H30FN3O3
Mol. Mass.391.4796
SMILESCCC(CC)O[C@@H]1C=C(C[C@H](N)[C@H]1NC(C)=O)C(=O)NCc1ccc(F)cc1 |r,c:7|
Structure
n/a