Reaction Details Report a problem with these data
Target
Sigma intracellular receptor 2
Ligand
BDBM50216056
Substrate
n/a
Meas. Tech.
ChEBML_1733120
Ki
0.260000±n/a nM
Citation
 Sun, YT; Wang, GF; Yang, YQ; Jin, F; Wang, Y; Xie, XY; Mach, RH; Huang, YS Synthesis and pharmacological evaluation of 6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline derivatives as sigma-2 receptor ligands. Eur J Med Chem 147:227-237 (2018) [PubMed]  Article 
Target
Name:
Sigma intracellular receptor 2
Synonyms:
MAC30 | Meningioma-associated protein 30 | S2R | SGMR2_HUMAN | Sigma-2 receptor | Sigma2 receptor | TMEM97 | Transmembrane protein 97
Type:
Protein
Mol. Mass.:
20857.20
Organism:
Homo sapiens (Human)
Description:
Q5BJF2
Residue:
176
Sequence:
MGAPATRRCVEWLLGLYFLSHIPITLFMDLQAVLPRELYPVEFRNLLKWYAKEFKDPLLQEPPAWFKSFLFCELVFQLPFFPIATYAFLKGSCKWIRTPAIIYSVHTMTTLIPILSTFLFEDFSKASGFKGQRPETLHERLTLVSVYAPYLLIPFILLIFMLRSPYYKYEEKRKKK
  
Inhibitor
Name:
BDBM50216056
Synonyms:
(N-[4-(6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)-butyl]-2-(2-fluoro-ethoxy)-3-methoxy-5-iodo-benzamide | CHEMBL227071
Type:
Small organic molecule
Emp. Form.:
C25H32FIN2O5
Mol. Mass.:
586.4349
SMILES:
COc1cc2CCN(CCCCNC(=O)c3cc(I)cc(OC)c3OCCF)Cc2cc1OC
Structure:
Search PDB for entries with ligand similarity: