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TargetCyclin-dependent kinase 19
LigandBDBM50353060
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1734994
IC50 8.0±n/a nM
Citation Hatcher, JMWang, ESJohannessen, LKwiatkowski, NSim, TGray, NS Development of Highly Potent and Selective Steroidal Inhibitors and Degraders of CDK8. ACS Med Chem Lett9:540-545 (2018) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Cyclin-dependent kinase 19
Name:Cyclin-dependent kinase 19
Synonyms:CDC2-related protein kinase 6 | CDC2L6 | CDK11 | CDK19 | Cell division cycle 2-like protein kinase 6 | Cell division protein kinase 19 | Cyclin-dependent kinase 11 | Death-preventing kinase | KIAA1028
Type:Serine/Threonine protein kinase
Mol. Mass.:56816.68
Organism:Homo sapiens (Human)
Description:Q9BWU1
Residue:502
Sequence:
MDYDFKAKLAAERERVEDLFEYEGCKVGRGTYGHVYKARRKDGKDEKEYALKQIEGTGIS
MSACREIALLRELKHPNVIALQKVFLSHSDRKVWLLFDYAEHDLWHIIKFHRASKANKKP
MQLPRSMVKSLLYQILDGIHYLHANWVLHRDLKPANILVMGEGPERGRVKIADMGFARLF
NSPLKPLADLDPVVVTFWYRAPELLLGARHYTKAIDIWAIGCIFAELLTSEPIFHCRQED
IKTSNPFHHDQLDRIFSVMGFPADKDWEDIRKMPEYPTLQKDFRRTTYANSSLIKYMEKH
KVKPDSKVFLLLQKLLTMDPTKRITSEQALQDPYFQEDPLPTLDVFAGCQIPYPKREFLN
EDDPEEKGDKNQQQQQNQHQQPTAPPQQAAAPPQAPPPQQNSTQTNGTAGGAGAGVGGTG
AGLQHSQDSSLNQVPPNKKPRLGPSGANSGGPVMPSDYQHSSSRLNYQSSVQGSSQSQST
LGYSSSSQQSSQYHPSHQAHRY
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50353060
NameBDBM50353060
Synonyms:CHEMBL4167193
TypeSmall organic molecule
Emp. Form.C30H40N2
Mol. Mass.428.652
SMILES[H][C@@]12CC[C@H](c3ccc4ccncc4c3)[C@@]1(C)CC[C@@]1([H])[C@@]2([H])CC=C2C[C@H](CC[C@]12C)N(C)C |r,t:28|
Structure
n/a