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Target
Aldo-keto reductase family 1 member B10
Ligand
BDBM50405246
Substrate
n/a
Meas. Tech.
ChEMBL_1738572 (CHEMBL4154322)
IC50
9610±n/a nM
Citation
 Crespo, I; Giménez-Dejoz, J; Porté, S; Cousido-Siah, A; Mitschler, A; Podjarny, A; Pratsinis, H; Kletsas, D; Parés, X; Ruiz, FX; Metwally, K; Farrés, J Design, synthesis, structure-activity relationships and X-ray structural studies of novel 1-oxopyrimido[4,5-c]quinoline-2-acetic acid derivatives as selective and potent inhibitors of human aldose reductase. Eur J Med Chem 152:160-174 (2018) [PubMed]  Article 
Target
Name:
Aldo-keto reductase family 1 member B10
Synonyms:
AK1BA_HUMAN | AKR1B10 | AKR1B11 | ARL-1 | ARP | Aldo-keto reductase family 1 member B10 | Aldo-keto reductase family 1 member B10 (AKR1B10) | Aldo-keto reductase family member 1B10 (AKR1B10) | Aldose reductase-like | Aldose reductase-related protein | SI reductase | Small intestine reductase | hARP
Type:
Protein
Mol. Mass.:
36024.67
Organism:
Homo sapiens (Human)
Description:
O60218. 1ZUA; 4JII; 4GQ0
Residue:
316
Sequence:
MATFVELSTKAKMPIVGLGTWKSPLGKVKEAVKVAIDAGYRHIDCAYVYQNEHEVGEAIQEKIQEKAVKREDLFIVSKLWPTFFERPLVRKAFEKTLKDLKLSYLDVYLIHWPQGFKSGDDLFPKDDKGNAIGGKATFLDAWEAMEELVDEGLVKALGVSNFSHFQIEKLLNKPGLKYKPVTNQVECHPYLTQEKLIQYCHSKGITVTAYSPLGSPDRPWAKPEDPSLLEDPKIKEIAAKHKKTAAQVLIRFHIQRNVIVIPKSVTPARIVENIQVFDFKLSDEEMATILSFNRNWRACNVLQSSHLEDYPFNAEY
  
Inhibitor
Name:
BDBM50405246
Synonyms:
CHEMBL4175230
Type:
Small organic molecule
Emp. Form.:
C20H13BrFN3O3
Mol. Mass.:
442.238
SMILES:
Cc1nc2c(nc3ccc(F)cc3c2c(=O)n1CC(O)=O)-c1ccc(Br)cc1
Structure:
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