Target
Aldo-keto reductase family 1 member B10
Ligand
BDBM50405253
Substrate
n/a
Meas. Tech.
ChEMBL_1738572 (CHEMBL4154322)
IC50
15000±n/a nM
Citation
 Crespo, IGiménez-Dejoz, JPorté, SCousido-Siah, AMitschler, APodjarny, APratsinis, HKletsas, DParés, XRuiz, FXMetwally, KFarrés, J Design, synthesis, structure-activity relationships and X-ray structural studies of novel 1-oxopyrimido[4,5-c]quinoline-2-acetic acid derivatives as selective and potent inhibitors of human aldose reductase. Eur J Med Chem 152:160-174 (2018) [PubMed]  Article 
Target
Name:
Aldo-keto reductase family 1 member B10
Synonyms:
AK1BA_HUMAN | AKR1B10 | AKR1B11 | ARL-1 | ARP | Aldo-keto reductase family 1 member B10 | Aldo-keto reductase family 1 member B10 (AKR1B10) | Aldo-keto reductase family member 1B10 (AKR1B10) | Aldose reductase-like | Aldose reductase-related protein | SI reductase | Small intestine reductase | hARP
Type:
Protein
Mol. Mass.:
36024.67
Organism:
Homo sapiens (Human)
Description:
O60218. 1ZUA; 4JII; 4GQ0
Residue:
316
Sequence:
MATFVELSTKAKMPIVGLGTWKSPLGKVKEAVKVAIDAGYRHIDCAYVYQNEHEVGEAIQEKIQEKAVKREDLFIVSKLWPTFFERPLVRKAFEKTLKDLKLSYLDVYLIHWPQGFKSGDDLFPKDDKGNAIGGKATFLDAWEAMEELVDEGLVKALGVSNFSHFQIEKLLNKPGLKYKPVTNQVECHPYLTQEKLIQYCHSKGITVTAYSPLGSPDRPWAKPEDPSLLEDPKIKEIAAKHKKTAAQVLIRFHIQRNVIVIPKSVTPARIVENIQVFDFKLSDEEMATILSFNRNWRACNVLQSSHLEDYPFNAEY
  
Inhibitor
Name:
BDBM50405253
Synonyms:
CHEMBL4170325
Type:
Small organic molecule
Emp. Form.:
C21H16ClN3O4
Mol. Mass.:
409.822
SMILES:
COc1ccc2nc(-c3ccc(Cl)cc3)c3nc(C)n(CC(O)=O)c(=O)c3c2c1
Structure:
Search PDB for entries with ligand similarity: